6AJ8
Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADP+, alpha-ketoglutarate and ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isocitrate dehydrogenase [NADP] | polymer | 413 | 46791.6 | 2 | UniProt (Q387G0) Pfam (PF00180) | Trypanosoma brucei brucei | |
| 2 | C, F (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, E (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | G (B) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 413 (UniProt: Q387G0)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | Met 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93583.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1713.1 | |
| All* | Total formula weight | 95296.2 |
