6AJ4

Crystal structure of the DHR-2 domain of DOCK7 in complex with Cdc42

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Dedicator of cytokinesis protein 7	polymer	290	33877.6	4	UniProt (Q96N67) Pfam (PF20422) Pfam (PF20421) In PDB	Homo sapiens (Human)
2	B, D, F, H	Cell division control protein 42 homolog	polymer	195	21461.5	4	UniProt (P60953) Pfam (PF00071) In PDB	Homo sapiens (Human)	G25K GTP-binding protein

Sequence modifications

A, C, E, G: 1801 - 2083 (UniProt: Q96N67)

PDB	External Database	Details
Gly 1794	-	expression tag
Ser 1795	-	expression tag
Ser 1796	-	expression tag
Gly 1797	-	expression tag
Ser 1798	-	expression tag
Ser 1799	-	expression tag
Gly 1800	-	expression tag

B, D, F, H: 1 - 188 (UniProt: P60953)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Ser 188	Cys 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	221356.4
All*	Total formula weight	221356.4

*Water molecules are not included.