6AGX
The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Fibroblast growth factor receptor 2 | polymer | 298 | 34549.5 | 4 | UniProt (P21802) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | A, B, C, D | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1H-imidazol-1-yl]acetate | non-polymer | 499.5 | 4 | Chemie (9WX) |
Sequence modifications
A, B, C, D: 467 - 764 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Thr 628 | Ala 628 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138198.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1998.2 | |
| All* | Total formula weight | 140196.1 |
