6AGX
The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 9WX A 800 |
| Chain | Residue |
| A | LEU487 |
| A | ALA643 |
| A | ASP644 |
| A | PHE645 |
| A | GLY488 |
| A | LYS517 |
| A | GLU534 |
| A | ILE548 |
| A | ALA567 |
| A | ARG630 |
| A | ASN631 |
| A | LEU633 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue 9WX B 800 |
| Chain | Residue |
| B | LEU487 |
| B | GLY488 |
| B | GLY490 |
| B | GLY493 |
| B | ALA515 |
| B | LYS517 |
| B | GLU534 |
| B | ILE548 |
| B | VAL564 |
| B | ALA567 |
| B | LEU633 |
| B | ALA643 |
| B | ASP644 |
| B | PHE645 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 9WX C 800 |
| Chain | Residue |
| C | LEU487 |
| C | GLY488 |
| C | ALA515 |
| C | LYS517 |
| C | GLU534 |
| C | ILE548 |
| C | VAL562 |
| C | VAL564 |
| C | TYR566 |
| C | ALA567 |
| C | ARG630 |
| C | LEU633 |
| C | ALA643 |
| C | ASP644 |
| C | PHE645 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue 9WX D 800 |
| Chain | Residue |
| D | LEU487 |
| D | GLY488 |
| D | ALA515 |
| D | LYS517 |
| D | GLU534 |
| D | ILE548 |
| D | VAL564 |
| D | ALA567 |
| D | ARG630 |
| D | LEU633 |
| D | ALA643 |
| D | ASP644 |
| D | PHE645 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK |
| Chain | Residue | Details |
| A | LEU487-LYS517 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLTARNVLV |
| Chain | Residue | Details |
| A | CYS622-VAL634 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"17803937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
