6AGF
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium channel protein type 4 subunit alpha | polymer | 1879 | 212836.4 | 1 | UniProt (P35499) Pfam (PF00520) Pfam (PF06512) In PDB | Homo sapiens (Human) | SkM1,Sodium channel protein skeletal muscle subunit alpha,Sodium channel protein type IV subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.4 |
2 | B | Sodium channel subunit beta-1 | polymer | 218 | 24732.1 | 1 | UniProt (Q07699) Pfam (PF07686) In PDB | Homo sapiens (Human) | |
3 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | A | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 6 | Chemie (6OU) | |||
6 | A | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | non-polymer | 544.8 | 1 | Chemie (9Z9) | |||
7 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 1836 (UniProt: P35499)
PDB | External Database | Details |
---|---|---|
Met -42 | - | expression tag |
Ala -41 | - | expression tag |
Ser -40 | - | expression tag |
Trp -39 | - | expression tag |
Ser -38 | - | expression tag |
His -37 | - | expression tag |
Pro -36 | - | expression tag |
Gln -35 | - | expression tag |
Phe -34 | - | expression tag |
Glu -33 | - | expression tag |
Lys -32 | - | expression tag |
Gly -31 | - | expression tag |
Gly -30 | - | expression tag |
Gly -29 | - | expression tag |
Ala -28 | - | expression tag |
Arg -27 | - | expression tag |
Gly -26 | - | expression tag |
Gly -25 | - | expression tag |
Ser -24 | - | expression tag |
Gly -23 | - | expression tag |
Gly -22 | - | expression tag |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Trp -19 | - | expression tag |
Ser -18 | - | expression tag |
His -17 | - | expression tag |
Pro -16 | - | expression tag |
Gln -15 | - | expression tag |
Phe -14 | - | expression tag |
Glu -13 | - | expression tag |
Lys -12 | - | expression tag |
Gly -11 | - | expression tag |
Phe -10 | - | expression tag |
Asp -9 | - | expression tag |
Tyr -8 | - | expression tag |
Lys -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Lys -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 237568.5 | |
Branched | Number of molecules | 3 |
Total formula weight | 1435.3 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 5295.2 | |
All* | Total formula weight | 244299.0 |