6AGF
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006936 | biological_process | muscle contraction |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0100001 | biological_process | regulation of skeletal muscle contraction by action potential |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0017080 | molecular_function | sodium channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 141 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| B | GLY19-GLU160 | |
| A | GLY1292-ALA1354 | |
| A | LYS1403-VAL1414 | |
| A | ARG1463-ALA1481 | |
| A | LEU1598-VAL1836 | |
| A | ARG179-PRO192 | |
| A | PRO234-ASP252 | |
| A | VAL445-PRO578 | |
| A | LEU629-TRP642 | |
| A | TRP683-GLY698 | |
| A | LEU798-TRP1032 | |
| A | LYS1083-ALA1096 | |
| A | PHE1143-SER1159 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| B | ILE161-TYR182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| B | LYS183-GLU218 | |
| A | TRP1116-GLY1123 | |
| A | ASN1180-VAL1230 | |
| A | ALA1253-LEU1269 | |
| A | GLU1373-ASP1383 | |
| A | LEU1433-THR1445 | |
| A | GLY1500-THR1521 | |
| A | ILE1545-GLY1574 | |
| A | ASP211-SER216 | |
| A | MET273-THR391 | |
| A | ARG417-TYR423 | |
| A | GLU598-ASN608 | |
| A | GLN663-GLY664 | |
| A | GLY718-ASP746 | |
| A | ASP768-CYS778 | |
| A | GLU1051-THR1063 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD |
| Chain | Residue | Details |
| B | ASN93 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30190309, ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0007744|PDB:6AGF, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD |
| Chain | Residue | Details |
| B | ASN110 | |
| B | ASN114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30765606, ECO:0000269|PubMed:36696443, ECO:0000269|PubMed:36823201, ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H, ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J, ECO:0007744|PDB:8FHD, ECO:0007744|PDB:8GZ1, ECO:0007744|PDB:8GZ2 |
| Chain | Residue | Details |
| B | ASN135 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | VAL253-PHE272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | PHE392-LEU416 | |
| A | PHE747-TRP767 | |
| A | GLY1231-ALA1252 | |
| A | PHE1522-PRO1544 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | MET424-ALA444 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | PHE579-MET597 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | VAL609-LYS628 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ASN643-VAL662 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | LEU665-SER682 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ALA699-VAL717 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | LEU779-PHE797 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | PHE1033-PHE1050 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ILE1064-LEU1082 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | TRP1097-ASN1115 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | PRO1124-ARG1142 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ILE1160-VAL1179 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | TYR1270-ILE1291 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | PHE1355-VAL1372 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ILE1384-LEU1402 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | GLY1415-ALA1432 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | LEU1446-ILE1462 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | LEU1482-PHE1499 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:30190309 |
| Chain | Residue | Details |
| A | ILE1575-ILE1597 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | SITE: Important for inhibition by tetrodotoxin => ECO:0000250|UniProtKB:P15390 |
| Chain | Residue | Details |
| A | TYR407 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250 |
| Chain | Residue | Details |
| A | SER1328 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN214 | |
| A | ASN288 | |
| A | ASN291 | |
| A | ASN297 | |
| A | ASN303 | |
| A | ASN315 | |
| A | ASN321 | |
| A | ASN333 | |
| A | ASN1191 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:30190309, ECO:0007744|PDB:6AGF |
| Chain | Residue | Details |
| A | ASN362 | |
| A | ASN1205 |
