6A9O
Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Superoxide dismutase [Cu-Zn] | polymer | 154 | 15958.8 | 10 | UniProt (P00441) Pfam (PF00080) | Homo sapiens (Human) | Superoxide dismutase 1,hSod1 |
| 2 | AA, BA, CA, K, O... (H, I, J, A, B...) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
| 3 | L, U (A, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | M, P, R, V (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | N, S, Z (A, C, F) | Dihydrogen tetrasulfide | non-polymer | 130.3 | 3 | Chemie (S4P) | |||
| 6 | X (F) | 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid | non-polymer | 434.4 | 1 | Chemie (6B3) | |||
| 7 | DA, EA, FA, GA, HA... (A, B, C, D, E...) | water | water | 18.0 | 1234 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 159587.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1938.6 | |
| All* | Total formula weight | 161526.2 |
