6A73

Complex structure of CSN2 with IP6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	COP9 signalosome complex subunit 2,Endolysin	polymer	304	35315.4	2	UniProt (P61201) UniProt (A0A097J809) Pfam (PF00959) UniProt (by SIFTS) (P00720)	Homo sapiens (Human)	Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15,Lysis protein,Lysozyme,Muramidase
2	C, E (A, B)	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	2	Chemie (IHP)
3	D, F (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	G, H (A, B)	water	water		18.0	171	Chemie (HOH)

Sequence modifications

A, B: 29 - 162 (UniProt: P61201)

PDB	External Database	Details
Met 28	-	initiating methionine

A, B: 163 - 325 (UniProt: A0A097J809)

PDB	External Database	Details
Thr 215	Cys 54	engineered mutation
Ala 258	Cys 97	engineered mutation
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70630.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1512.2
All*	Total formula weight	72143.0

*Water molecules are not included.