6A4I
Crystal Structure of human TDO inhibitor complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Tryptophan 2,3-dioxygenase | polymer | 391 | 46169.6 | 4 | UniProt (P48775) Pfam (PF03301) In PDB | Homo sapiens (Human) | TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TRPO,Tryptophan pyrrolase,Tryptophanase |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C, D | 1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol | non-polymer | 250.7 | 4 | Chemie (9R9) | |||
4 | A, B, D | TRYPTOPHAN | non-polymer | 204.2 | 3 | Chemie (TRP) | |||
5 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) |
Sequence modifications
A, B, C, D: 19 - 388 (UniProt: P48775)
PDB | External Database | Details |
---|---|---|
Met -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Ser 8 | - | expression tag |
Ser 9 | - | expression tag |
Gly 10 | - | expression tag |
Leu 11 | - | expression tag |
Val 12 | - | expression tag |
Pro 13 | - | expression tag |
Arg 14 | - | expression tag |
Gly 15 | - | expression tag |
Ser 16 | - | expression tag |
His 17 | - | expression tag |
Met 18 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 184678.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4273.6 | |
All* | Total formula weight | 188952.1 |