6A3A
MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTP-binding nuclear protein Ran | polymer | 235 | 26404.2 | 1 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
| 2 | B (B) | Ran-specific GTPase-activating protein 1 | polymer | 143 | 16521.9 | 1 | UniProt (P41920) Pfam (PF00638) | Saccharomyces cerevisiae (Baker's yeast) | Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1 |
| 3 | C (C) | Exportin-1 | polymer | 1003 | 115052.3 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124 |
| 4 | D (D) | MVM NES mutant Nm2 | polymer | 20 | 2141.4 | 1 | UniProt (by SIFTS) (P0DJZ2) | Minute virus of mice | |
| 5 | E (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 7 | G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 8 | H (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 9 | I (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 10 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
B: 62 - 201 (UniProt: P41920)
C: 1 - 1058 (UniProt: P30822)
| PDB | External Database | Details |
|---|---|---|
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 197 | Tyr 197 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 59 | - | expression tag |
| Gly 60 | - | expression tag |
| Ser 61 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Val 377 | deletion |
| - | Gln 378 | deletion |
| - | Arg 379 | deletion |
| - | Leu 380 | deletion |
| - | Pro 381 | deletion |
| - | Ala 382 | deletion |
| - | Thr 383 | deletion |
| - | Glu 384 | deletion |
| - | Met 385 | deletion |
| - | Ser 386 | deletion |
| - | Pro 387 | deletion |
| - | Leu 388 | deletion |
| - | Ile 389 | deletion |
| - | Gln 390 | deletion |
| - | Leu 391 | deletion |
| - | Ser 392 | deletion |
| - | Val 393 | deletion |
| - | Gly 394 | deletion |
| - | Ser 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| - | Ile 398 | deletion |
| - | Ser 399 | deletion |
| - | Thr 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Gly 403 | deletion |
| - | Ala 404 | deletion |
| - | Leu 405 | deletion |
| - | Asn 406 | deletion |
| - | Pro 407 | deletion |
| - | Glu 408 | deletion |
| - | Tyr 409 | deletion |
| - | Met 410 | deletion |
| - | Lys 411 | deletion |
| - | Arg 412 | deletion |
| - | Phe 413 | deletion |
| - | Val 441 | deletion |
| - | Leu 442 | deletion |
| - | Val 443 | deletion |
| - | Val 444 | deletion |
| - | Glu 445 | deletion |
| - | Asn 446 | deletion |
| - | Asp 447 | deletion |
| - | Glu 448 | deletion |
| - | Gly 449 | deletion |
| - | Glu 450 | deletion |
| - | Ile 451 | deletion |
| - | Val 452 | deletion |
| - | Arg 453 | deletion |
| - | Glu 454 | deletion |
| - | Phe 455 | deletion |
| - | Val 456 | deletion |
| - | Lys 457 | deletion |
| - | Glu 458 | deletion |
| - | Ser 459 | deletion |
| - | Asp 460 | deletion |
| - | Thr 461 | deletion |
| Gly 537 | Asp 537 | engineered mutation |
| Cys 539 | Thr 539 | engineered mutation |
| Glu 540 | Val 540 | engineered mutation |
| Gln 541 | Lys 541 | engineered mutation |
| Cys 1022 | Tyr 1022 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160119.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 724.6 | |
| All* | Total formula weight | 160844.3 |
