5ZUN
Crystal structure of human monoacylglycerol lipase in complex with compound 3l
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Monoglyceride lipase | polymer | 305 | 33335.3 | 1 | UniProt (Q99685) Pfam (PF12146) In PDB | Homo sapiens (Human) | MGL,HU-K5,Lysophospholipase homolog,Lysophospholipase-like,Monoacylglycerol lipase,MAGL |
| 2 | A | (4R)-1-(2'-chloro[1,1'-biphenyl]-3-yl)-4-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]pyrrolidin-2-one | non-polymer | 467.0 | 1 | Chemie (9JX) | |||
| 3 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: Q99685)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 36 | Lys 36 | engineered mutation |
| Ser 169 | Leu 169 | engineered mutation |
| Ser 176 | Leu 176 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33335.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1193.2 | |
| All* | Total formula weight | 34528.5 |
