5ZUN

Crystal structure of human monoacylglycerol lipase in complex with compound 3l

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006639	biological_process	acylglycerol metabolic process
A	0006954	biological_process	inflammatory response
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0019369	biological_process	arachidonic acid metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046464	biological_process	acylglycerol catabolic process
A	0047372	molecular_function	acylglycerol lipase activity
A	0050727	biological_process	regulation of inflammatory response
A	0051930	biological_process	regulation of sensory perception of pain
A	0052651	biological_process	monoacylglycerol catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	2000124	biological_process	regulation of endocannabinoid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue 9JX A 401

Chain	Residue
A	GLY50
A	PRO178
A	ILE179
A	SER181
A	LEU184
A	SER185
A	GLU190
A	VAL191
A	TYR194
A	LEU205
A	LEU241
A	ALA51
A	VAL270
A	LYS273
A	PG4402
A	HOH542
A	HOH585
A	GLU53
A	ARG57
A	MET88
A	HIS121
A	SER122
A	MET123
A	GLY177

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PG4 A 402

Chain	Residue
A	THR158
A	9JX401
A	EDO403
A	HOH501
A	HOH519
A	HOH532

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 403

Chain	Residue
A	ILE179
A	ASP180
A	PG4402
A	HOH522
A	HOH673

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 404

Chain	Residue
A	GLU190
A	HIS272
A	LYS273
A	PHE283
A	HOH546
A	HOH658

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 405

Chain	Residue
A	GLN12
A	GLY81
A	ARG87
A	LEU199
A	HOH565
A	HOH621
A	HOH677

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	ILE14
A	HOH563
A	HOH589
A	HOH597
A	HOH632

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 407

Chain	Residue
A	TYR34
A	HIS103
A	SER106
A	MET107
A	SER196
A	ARG202
A	HOH508
A	HOH574

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 408

Chain	Residue
A	HIS54
A	GLY56
A	ARG57
A	ILE193
A	ASP197

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 409

Chain	Residue
A	ARG9
A	THR10
A	PRO11
A	GLU84
A	GLY85

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 410

Chain	Residue
A	ASN215
A	ARG219
A	ARG222

---

site_id	AD2
Number of Residues	3
Details	binding site for residue CL A 411

Chain	Residue
A	HIS94
A	ARG219
A	HOH791

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLLGHSMGG

Chain	Residue	Details
A	VAL116-GLY125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:19957260

Chain	Residue	Details
A	SER122

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:19957260

Chain	Residue	Details
A	ASP239
A	HIS269

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35678

Chain	Residue	Details
A	THR10

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:O35678

Chain	Residue	Details
A	TYR58

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