5ZSI
Crystal structure of monkey TLR7 in complex with CL097
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Toll-like receptor 7 | polymer | 823 | 94745.6 | 2 | UniProt (B3Y653) Pfam (PF13855) In PDB | Macaca mulatta (Rhesus macaque) | |
2 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
3 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) | |||
4 | B, A | 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine | non-polymer | 242.3 | 2 | Chemie (C09) | |||
5 | B, A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
6 | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
B, A: 27 - 839 (UniProt: B3Y653)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Gln 167 | Asn 167 | engineered mutation |
Gln 389 | Asn 389 | engineered mutation |
Leu 440 | Ser 440 | see sequence details |
Val 441 | Glu 441 | see sequence details |
Pro 442 | Val 442 | see sequence details |
Arg 443 | Gly 443 | see sequence details |
Gly 444 | Phe 444 | see sequence details |
Ser 445 | Cys 445 | see sequence details |
Gln 488 | Asn 488 | engineered mutation |
Gln 799 | Asn 799 | engineered mutation |
Glu 840 | - | expression tag |
Phe 841 | - | expression tag |
Leu 842 | - | expression tag |
Val 843 | - | expression tag |
Pro 844 | - | expression tag |
Arg 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 189491.2 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 3398.2 | |
All* | Total formula weight | 193313.7 |