5ZPU
LFS829 in complex with CRM1-Ran-RanBP1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTP-binding nuclear protein Ran | polymer | 216 | 24414.0 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
2 | B | Ran-specific GTPase-activating protein 1 | polymer | 140 | 16320.7 | 1 | UniProt (P41920) Pfam (PF00638) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome stability protein 20,Perinuclear array-localized protein,Ran-binding protein 1,RANBP1 |
3 | C | Exportin-1,Exportin-1 | polymer | 1024 | 117442.8 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Chromosome region maintenance protein 1,Karyopherin-124,Chromosome region maintenance protein 1,Karyopherin-124 |
4 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | C | (Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol | non-polymer | 375.4 | 1 | Chemie (D29) | |||
7 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | water | water | 18.0 | 310 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
C: 1 - 376 (UniProt: P30822)
C: 414 - 1058 (UniProt: P30822)
PDB | External Database | Details |
---|---|---|
Ala 182 | Leu 182 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 537 | Asp 537 | engineered mutation |
Cys 539 | Thr 539 | engineered mutation |
Glu 540 | Val 540 | engineered mutation |
Gln 541 | Lys 541 | engineered mutation |
Cys 1022 | Tyr 1022 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 158177.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 958.3 | |
All* | Total formula weight | 159135.8 |