5ZNN

Crystal structure of ligand-free form of the Vps10 ectodomain of Sortilin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sortilin	polymer	679	75897.9	2	UniProt (Q6PHU5) Pfam (PF15902) Pfam (PF15901)	Mus musculus (Mouse)	Neurotensin receptor 3,mNTR3
2	C, E, F, G (C, E, F, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
3	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	H, I, P (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	J, K, L, Q, R (A, B)	SODIUM ION	non-polymer		23.0	5	Chemie (NA)
6	M, N, O, S (A, B)	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
7	T, U (A, B)	water	water		18.0	434	Chemie (HOH)

Sequence modifications

A, B: 76 - 744 (UniProt: Q6PHU5)

PDB	External Database	Details
Ile 745	-	expression tag
Glu 746	-	expression tag
Gly 747	-	expression tag
Arg 748	-	expression tag
His 749	-	expression tag
His 750	-	expression tag
His 751	-	expression tag
His 752	-	expression tag
His 753	-	expression tag
His 754	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	151795.7
Branched	Number of molecules	5
	Total formula weight	2770.6
Non-Polymers*	Number of molecules	12
	Total formula weight	1014.8
All*	Total formula weight	155581.0

*Water molecules are not included.