5ZMQ
Crystal structure of Zika NS3 protease with phenylacetyl-Lys-Lys-Arg-COOH inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Serine protease subunit NS2B | polymer | 53 | 5865.4 | 4 | UniProt (Q32ZE1) Pfam (PF01002) | Zika virus (ZIKV) | |
| 2 | B, D, F, H (B, D, F, H) | Serine protease NS3 | polymer | 178 | 19021.5 | 4 | UniProt (H8XX12) Pfam (PF00949) UniProt (by SIFTS) (Q32ZE1) | Zika virus (strain Mr 766) (ZIKV) | |
| 3 | I, J (I, K) | peptide PAC-DLY-DLY-DAR | polymer | 4 | 549.7 | 2 | BIRD (PRD_002309) | synthetic construct | |
| 4 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 499 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 46 - 96 (UniProt: Q32ZE1)
B, D, F, H: 1 - 177 (UniProt: H8XX12)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | expression tag |
| Thr 45 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 143 | Cys 1639 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 100647.0 | |
| All* | Total formula weight | 100647.0 |
