5ZKP

Crystal structure of the human platelet-activating factor receptor in complex with SR 27417

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor	polymer	466	52430.5	1	UniProt (P25105) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) In PDB	Homo sapiens (Human)	PAFr,PAFr
2	A	N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine	non-polymer		464.7	1	Chemie (9ER)
3	A	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)

Sequence modifications

A: 2 - 216 (UniProt: P25105)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Tyr 116	Phe 116	engineered mutation
Asp 169	Asn 169	engineered mutation

A: 1001 - 1147 (UniProt: P00323)

PDB	External Database	Details
Ala 1001	Pro 2	engineered mutation
Trp 1097	Tyr 98	engineered mutation

A: 224 - 316 (UniProt: P25105)

PDB	External Database	Details
Asp 230	Ala 230	engineered mutation
Ala 234	Val 234	engineered mutation
Asn 289	Asp 289	engineered mutation
Glu 317	-	expression tag
Phe 318	-	expression tag
Leu 319	-	expression tag
Glu 320	-	expression tag
Val 321	-	expression tag
Leu 322	-	expression tag
Phe 323	-	expression tag
Gln 324	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52430.5
Non-Polymers*	Number of molecules	2
	Total formula weight	921.1
All*	Total formula weight	53351.5

*Water molecules are not included.