5ZHX
Crystal structure of SmgGDS-558 and farnesylated RhoA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Rap1 GTPase-GDP dissociation stimulator 1 | polymer | 487 | 53418.9 | 4 | UniProt (P52306) Pfam (PF00514) | Homo sapiens (Human) | Exchange factor smgGDS,SMG GDS protein,SMG P21 stimulatory GDP/GTP exchange protein |
| 2 | E, F, G, H (e, f, g, h) | Transforming protein RhoA | polymer | 198 | 22168.5 | 4 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (Human) | Rho cDNA clone 12,h12 |
| 3 | I, J, K, L (e, f, g, h) | FARNESYL | non-polymer | 206.4 | 4 | Chemie (FAR) |
Sequence modifications
A, B, C, D: 77 - 558 (UniProt: P52306)
e, f, g, h: 1 - 193 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Gly 72 | - | expression tag |
| Pro 73 | - | expression tag |
| Leu 74 | - | expression tag |
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 193 | Leu 193 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 302349.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 825.5 | |
| All* | Total formula weight | 303175.4 |
