5ZG6
Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as "post-acylation" intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Beta-lactamase | polymer | 268 | 29861.9 | 2 | UniProt (P00808) Pfam (PF00144) | Bacillus licheniformis | Penicillinase |
| 2 | C, D (B, A) | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID | non-polymer | 340.4 | 2 | Chemie (CED) | |||
| 3 | E, F (B, A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
B, A: 26 - 295 (UniProt: P00808)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Met 25 | - | expression tag |
| Tyr 166 | Glu 180 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59723.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 680.8 | |
| All* | Total formula weight | 60404.6 |
