5ZG6
Crystal structure of beta-lactamase PenP mutant-E166Y in complex with cephaloridine as "post-acylation" intermediate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005886 | cellular_component | plasma membrane |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
A | 0046677 | biological_process | response to antibiotic |
B | 0005886 | cellular_component | plasma membrane |
B | 0008800 | molecular_function | beta-lactamase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0017001 | biological_process | antibiotic catabolic process |
B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue CED B 301 |
Chain | Residue |
A | ASP114 |
B | THR235 |
B | GLY236 |
B | ALA237 |
B | ARG244 |
B | ALA69 |
B | SER70 |
B | TYR105 |
B | SER130 |
B | ASN132 |
B | TYR166 |
B | ASN170 |
B | LYS234 |
site_id | AC2 |
Number of Residues | 17 |
Details | binding site for Di-peptide CED A 301 and SER A 70 |
Chain | Residue |
A | PHE68 |
A | ALA69 |
A | THR71 |
A | ILE72 |
A | LYS73 |
A | TYR105 |
A | SER130 |
A | ASN132 |
A | TYR166 |
A | ASN170 |
A | LYS234 |
A | THR235 |
A | GLY236 |
A | ALA237 |
A | ARG244 |
A | HOH401 |
B | ASP114 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Acyl-ester intermediate |
Chain | Residue | Details |
B | SER70 | |
A | SER70 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
B | GLU168 | |
A | GLU168 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
B | LYS234 | |
A | LYS234 |