5ZEN
Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA topoisomerase 2-beta | polymer | 803 | 91928.4 | 1 | UniProt (Q02880) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) In PDB | Homo sapiens (Human) | DNA topoisomerase II,beta isozyme |
| 2 | B | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3') | polymer | 8 | 2436.6 | 1 | synthetic construct | ||
| 3 | C | DNA (5'-D(P*AP*GP*CP*TP*CP*GP*GP*CP*T)-3') | polymer | 9 | 2731.8 | 1 | synthetic construct | ||
| 4 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 445 - 1201 (UniProt: Q02880)
| PDB | External Database | Details |
|---|---|---|
| Met 419 | - | expression tag |
| Ala 420 | - | expression tag |
| Ser 421 | - | expression tag |
| Trp 422 | - | expression tag |
| Ser 423 | - | expression tag |
| His 424 | - | expression tag |
| Pro 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Phe 427 | - | expression tag |
| Glu 428 | - | expression tag |
| Lys 429 | - | expression tag |
| Gly 430 | - | expression tag |
| Ala 431 | - | expression tag |
| Asp 432 | - | expression tag |
| Asp 433 | - | expression tag |
| Asp 434 | - | expression tag |
| Asp 435 | - | expression tag |
| Lys 436 | - | expression tag |
| Val 437 | - | expression tag |
| Pro 438 | - | expression tag |
| Asp 439 | - | expression tag |
| Pro 440 | - | expression tag |
| Thr 441 | - | expression tag |
| Ser 442 | - | expression tag |
| Val 443 | - | expression tag |
| Asp 444 | - | expression tag |
| Gly 1202 | - | expression tag |
| Ala 1203 | - | expression tag |
| Pro 1204 | - | expression tag |
| Gly 1205 | - | expression tag |
| Phe 1206 | - | expression tag |
| Ser 1207 | - | expression tag |
| Ser 1208 | - | expression tag |
| Ile 1209 | - | expression tag |
| Ser 1210 | - | expression tag |
| Ala 1211 | - | expression tag |
| His 1212 | - | expression tag |
| His 1213 | - | expression tag |
| His 1214 | - | expression tag |
| His 1215 | - | expression tag |
| His 1216 | - | expression tag |
| His 1217 | - | expression tag |
| His 1218 | - | expression tag |
| His 1219 | - | expression tag |
| His 1220 | - | expression tag |
| His 1221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 97096.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 109.9 | |
| All* | Total formula weight | 97206.7 |
