5ZCS

4.9 Angstrom Cryo-EM structure of human mTOR complex 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Serine/threonine-protein kinase mTOR	polymer	2549	289258.0	2	UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2	C, D	Target of rapamycin complex subunit LST8	polymer	326	35910.1	2	UniProt (Q9BVC4) Pfam (PF00400) In PDB	Homo sapiens (Human)	TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	E, F	Rapamycin-insensitive companion of mTOR	polymer	1708	175142.5	2	UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) In PDB	Homo sapiens (Human)	AVO3 homolog,hAVO3
4	G, H	Target of rapamycin complex 2 subunit MAPKAP1	polymer	522	55158.5	2	UniProt (Q9BPZ7) Pfam (PF16978) Pfam (PF16979) In PDB	Homo sapiens (Human)	SIN:Stress-activated map kinase-interacting protein 1,TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,mSIN1

Sequence modifications

E, F: 1 - 1018 (UniProt: Q6R327)
E, F: 1019 - 1708 (PDB: 5ZCS)
G, H: 1 - 140 (PDB: 5ZCS)
G, H: 141 - 522 (UniProt: Q9BPZ7)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	1110938.1
All*	Total formula weight	1110938.1

*Water molecules are not included.