Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5ZCS

4.9 Angstrom Cryo-EM structure of human mTOR complex 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0001932biological_processregulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0007584biological_processresponse to nutrient
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009791biological_processpost-embryonic development
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016605cellular_componentPML body
A0018105biological_processpeptidyl-serine phosphorylation
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030163biological_processprotein catabolic process
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045948biological_processpositive regulation of translational initiation
A0046777biological_processprotein autophosphorylation
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048511biological_processrhythmic process
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050882biological_processvoluntary musculoskeletal movement
A0051128biological_processregulation of cellular component organization
A0051219molecular_functionphosphoprotein binding
A0051247biological_processpositive regulation of protein metabolic process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051647biological_processnucleus localization
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1904059biological_processregulation of locomotor rhythm
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000785biological_processregulation of autophagosome assembly
B0000139cellular_componentGolgi membrane
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0001932biological_processregulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006468biological_processprotein phosphorylation
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007040biological_processlysosome organization
B0007281biological_processgerm cell development
B0007584biological_processresponse to nutrient
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009791biological_processpost-embryonic development
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010628biological_processpositive regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016605cellular_componentPML body
B0018105biological_processpeptidyl-serine phosphorylation
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030163biological_processprotein catabolic process
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035264biological_processmulticellular organism growth
B0038202biological_processTORC1 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0044877molecular_functionprotein-containing complex binding
B0045335cellular_componentphagocytic vesicle
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045948biological_processpositive regulation of translational initiation
B0046777biological_processprotein autophosphorylation
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048511biological_processrhythmic process
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050882biological_processvoluntary musculoskeletal movement
B0051128biological_processregulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051247biological_processpositive regulation of protein metabolic process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051647biological_processnucleus localization
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0106310molecular_functionprotein serine kinase activity
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1904059biological_processregulation of locomotor rhythm
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990253biological_processcellular response to leucine starvation
B2000785biological_processregulation of autophagosome assembly
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006974biological_processDNA damage response
C0007010biological_processcytoskeleton organization
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0030307biological_processpositive regulation of cell growth
C0030838biological_processpositive regulation of actin filament polymerization
C0031669biological_processcellular response to nutrient levels
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0032008biological_processpositive regulation of TOR signaling
C0032956biological_processregulation of actin cytoskeleton organization
C0038202biological_processTORC1 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045821biological_processpositive regulation of glycolytic process
C0046889biological_processpositive regulation of lipid biosynthetic process
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0071456biological_processcellular response to hypoxia
C0071470biological_processcellular response to osmotic stress
C1905857biological_processpositive regulation of pentose-phosphate shunt
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006974biological_processDNA damage response
D0007010biological_processcytoskeleton organization
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0030307biological_processpositive regulation of cell growth
D0030838biological_processpositive regulation of actin filament polymerization
D0031669biological_processcellular response to nutrient levels
D0031929biological_processTOR signaling
D0031931cellular_componentTORC1 complex
D0031932cellular_componentTORC2 complex
D0032008biological_processpositive regulation of TOR signaling
D0032956biological_processregulation of actin cytoskeleton organization
D0038202biological_processTORC1 signaling
D0043066biological_processnegative regulation of apoptotic process
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045821biological_processpositive regulation of glycolytic process
D0046889biological_processpositive regulation of lipid biosynthetic process
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0071456biological_processcellular response to hypoxia
D0071470biological_processcellular response to osmotic stress
D1905857biological_processpositive regulation of pentose-phosphate shunt
E0031929biological_processTOR signaling
E0031932cellular_componentTORC2 complex
F0031929biological_processTOR signaling
F0031932cellular_componentTORC2 complex
G0031932cellular_componentTORC2 complex
H0031932cellular_componentTORC2 complex
Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVDLDS
ChainResidueDetails
GVAL333-SER339

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
CMET100-LEU114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU2185
AGLU2190
ATYR2225
AGLY2238
ATRP2239
AVAL2240
ATHR2245
AMET2345
AILE2356
BSER2165
BGLN2167
BLEU2185
BGLU2190
BTYR2225
BGLY2238
BTRP2239
BVAL2240
BTHR2245
BMET2345
BILE2356
GSER186
HSER186

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
FLYS274
BLYS2187
BASN2343
BASP2357
GSER510
HSER510

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER567
BSER567

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ATHR1162
BTHR1162

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS1218
BLYS1218

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19487463, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1261
BSER1261

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:29150432
ChainResidueDetails
ASER2159
BSER2159

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:21576368
ChainResidueDetails
ATHR2164
BTHR2164

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:24247430
ChainResidueDetails
ATHR2173
BTHR2173

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by RPS6KB1 => ECO:0000269|PubMed:15905173
ChainResidueDetails
ATHR2446
BTHR2446

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; by RPS6KB1 => ECO:0000269|PubMed:15905173, ECO:0000269|PubMed:19145465, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER2448
BSER2448

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER2478
BSER2478

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:21576368, ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER2481
BSER2481

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon