5ZBH

The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Neuropeptide Y receptor type 1,T4 Lysozyme,Neuropeptide Y receptor type 1	polymer	527	60665.0	1	UniProt (P25929) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720)	Homo sapiens (Human)	NPY1-R,Lysis protein,Lysozyme,Muramidase,NPY1-R
2	B (A)	dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate	non-polymer		590.7	1	Chemie (9AF)

Sequence modifications

A: 2 - 241 (UniProt: P25929)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Trp 129	Phe 129	engineered mutation

A: 1001 - 1160 (UniProt: D9IEF7)

PDB	External Database	Details
Thr 1053	Cys 54	engineered mutation
Ala 1096	Cys 97	engineered mutation

A: 250 - 358 (UniProt: P25929)

PDB	External Database	Details
Glu 359	-	expression tag
Phe 360	-	expression tag
Leu 361	-	expression tag
Glu 362	-	expression tag
Val 363	-	expression tag
Leu 364	-	expression tag
Phe 365	-	expression tag
Gln 366	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60665.0
Non-Polymers*	Number of molecules	1
	Total formula weight	590.7
All*	Total formula weight	61255.7

*Water molecules are not included.