5ZBH

The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 9AF A 1201

Chain	Residue
A	PRO117
A	TYR220
A	THR280
A	PHE282
A	ASN283
A	THR284
A	PHE286
A	ASP287
A	ALA294
A	HIS298
A	ASN299
A	GLN120
A	PHE302
A	CYS121
A	ILE124
A	PHE173
A	ASP200
A	THR212
A	LEU215
A	GLN219

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Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSIwSLVLIAVERHQlI

Chain	Residue	Details
A	VAL126-ILE142

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	LEU45-ILE65

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LEU66-ASN76
A	ARG138-HIS154

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	ILE77-THR97

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site_id	SWS_FT_FI4
Number of Residues	70
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	PHE98-ASN116
A	TYR176-TYR211
A	PHE282-ASN299

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	PRO117-GLU137

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	ALA155-ILE175

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	THR212-PHE232

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	ILE261-ILE281

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site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	LEU300-TYR320

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site_id	SWS_FT_FI10
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS338

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site_id	SWS_FT_FI11
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN2
A	ASN11
A	ASN17

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1010

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site_id	SWS_FT_FI13
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP1019

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1031
A	PHE1103

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1116
A	ASN1131

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1010	proton shuttle (general acid/base)
A	ASP1019	covalent catalysis

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