5YVU
Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Genome polyprotein | polymer | 627 | 70044.8 | 1 | UniProt (F8TEL4) | Dengue virus 4 | |
| 2 | B (A) | Genome polyprotein | polymer | 55 | 5964.5 | 1 | UniProt (F8TEL4) | Dengue virus 4 | |
| 3 | C (I) | Pancreatic trypsin inhibitor | polymer | 55 | 6342.4 | 1 | UniProt (P00974) Pfam (PF00014) | Bos taurus (Bovine) | Aprotinin,Basic protease inhibitor,BPTI |
| 4 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F, G (B, A, I) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
B: 1 - 618 (UniProt: F8TEL4)
A: 49 - 95 (UniProt: F8TEL4)
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 135 | Ser 1609 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Phe 41 | - | expression tag |
| Lys 42 | - | expression tag |
| Pro 43 | - | expression tag |
| Gly 44 | - | expression tag |
| Thr 45 | - | expression tag |
| Ser 46 | - | expression tag |
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 82351.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 82443.7 |
