5YRS

X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate

Replaces:  3MIM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PROTEASE	polymer	104	11163.1	1	UniProt (P04585) Pfam (PF00077)	Human immunodeficiency virus 1 (HIV-1)	RETROPEPSIN, PR
2	B (B)	PROTEASE	polymer	104	11103.0	1	UniProt (P04585) Pfam (PF00077)	Human immunodeficiency virus 1 (HIV-1)	RETROPEPSIN, PR
3	C (X)	RT-RH oligopeprtide	polymer	6	774.8	1	UniProt (by SIFTS) (P04585)	Human immunodeficiency virus 1
4	D, E, F (A, B, X)	water	water		18.0	193	Chemie (HOH)

Sequence modifications

A: 1 - 99 (UniProt: P04585)

PDB	External Database	Details
Met 95	Cys 583	engineered mutation
Gly 100	-	expression tag
Gly 101	-	expression tag
Ser 102	-	expression tag
Ser 103	-	expression tag
Gly 104	-	expression tag

B: 1001 - 1099 (UniProt: P04585)

PDB	External Database	Details
Ala 1095	Cys 583	engineered mutation
Gly 1100	-	expression tag
Gly 1101	-	expression tag
Ser 1102	-	expression tag
Ser 1103	-	expression tag
Gly 1104	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	23040.9
All*	Total formula weight	23040.9

*Water molecules are not included.