5YRS

X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate

Replaces:  3MIM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL

Chain	Residue	Details
B	ALA1022-LEU1033
A	ALA22-LEU33

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
X	ASP7

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by viral protease; partial => ECO:0000250

Chain	Residue	Details
X	HPH4

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain	Residue	Details
B	ASP1025	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	THR1026	electrostatic stabiliser, transition state stabiliser
B	GLY1027	electrostatic stabiliser, hydrogen bond donor

---