5YR4
Human methionine aminopeptidase type 1b (F309M mutant) in complex with TNP470
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methionine aminopeptidase 1 | polymer | 304 | 34162.9 | 1 | UniProt (P53582) Pfam (PF00557) | Homo sapiens (Human) | MetAP 1,Peptidase M 1 |
| 2 | B, C, D, E (A) | COBALT (II) ION | non-polymer | 58.9 | 4 | Chemie (CO) | |||
| 3 | F (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H (A) | (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate | non-polymer | 403.9 | 1 | Chemie (TN4) | |||
| 6 | I (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 90 - 393 (UniProt: P53582)
| PDB | External Database | Details |
|---|---|---|
| Met 309 | Phe 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34162.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 770.8 | |
| All* | Total formula weight | 34933.8 |
