5YQZ

Structure of the glucagon receptor in complex with a glucagon analogue

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Glucagon receptor,Endolysin,Glucagon receptor	polymer	575	65799.1	1	UniProt (P47871) UniProt (D9IEF7) Pfam (PF02793) Pfam (PF00002) Pfam (PF00959) UniProt (by SIFTS) (P00720)	Homo sapiens (Human)	GL-R,Lysis protein,Lysozyme,Muramidase
2	B (P)	Glucagon analogue	polymer	28	3345.7	1	Pfam (PF00123) UniProt (by SIFTS) (P01275)	Homo sapiens
3	C, D (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	E, F, G, H, I... (R)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	6	Chemie (OLC)
5	K (R)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)

Sequence modifications

R: 27 - 257 (UniProt: P47871)

PDB	External Database	Details
Gly 24	-	expression tag
Ala 25	-	expression tag
Pro 26	-	expression tag
Ala 173	Arg 173	engineered mutation

R: 1001 - 1160 (UniProt: D9IEF7)

PDB	External Database	Details
Thr 1053	Cys 54	engineered mutation
Ala 1096	Cys 97	engineered mutation

R: 260 - 432 (UniProt: P47871)

PDB	External Database	Details
Glu 433	-	expression tag
Phe 434	-	expression tag
Leu 435	-	expression tag
Glu 436	-	expression tag
Val 437	-	expression tag
Leu 438	-	expression tag
Phe 439	-	expression tag
Gln 440	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69144.7
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	7
	Total formula weight	2234.2
All*	Total formula weight	72227.7

*Water molecules are not included.