5YQZ

Structure of the glucagon receptor in complex with a glucagon analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region
R	0003796	molecular_function	lysozyme activity
R	0003824	molecular_function	catalytic activity
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0009253	biological_process	peptidoglycan catabolic process
R	0016020	cellular_component	membrane
R	0016787	molecular_function	hydrolase activity
R	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
R	0016998	biological_process	cell wall macromolecule catabolic process
R	0030430	cellular_component	host cell cytoplasm
R	0031640	biological_process	killing of cells of another organism
R	0042742	biological_process	defense response to bacterium
R	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PROSITE/UniProt

site_id	PS00649
Number of Residues	25
Details	G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtFDkys.CWpdTpanttanisCP

Chain	Residue	Details
R	CYS58-PRO82

---

site_id	PS00650
Number of Residues	16
Details	G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVaVLYCFlNkeV

Chain	Residue	Details
R	GLN392-VAL407

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	34
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	54
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"23863937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Region: {"description":"Important for allosteric inhibitor binding","evidences":[{"source":"PubMed","id":"27111510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22908259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28514451","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ERS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P55095","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain

Residue

Details

---