5YLT
Crystal structure of SET7/9 in complex with a cyproheptadine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETD7 | polymer | 263 | 29083.2 | 1 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (Human) | Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9 |
| 2 | B (A) | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) PubChem (25246236) PubChem (46875078) PubChem (46936257) PubChem (176612030) PubChem (177116271) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (70602121) PubChem (12771338) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (456189) PubChem (4065234) PubChem (6917665) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (12771337) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605) | |||
| 3 | C (A) | 2-(1-methylpiperidin-4-ylidene)tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-6-ol | non-polymer | 303.4 | 1 | Chemie (C7N) PubChem (85727193) | |||
| 4 | D, E, F (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 5 | G (A) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 111 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | expression tag |
| Ser 105 | - | expression tag |
| Ser 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gly 110 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29083.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 961.1 | |
| All* | Total formula weight | 30044.3 |
