5YLT
Crystal structure of SET7/9 in complex with a cyproheptadine derivative
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue SFG A 401 |
Chain | Residue |
A | ILE223 |
A | TYR335 |
A | TRP352 |
A | GLU356 |
A | GLN364 |
A | HOH512 |
A | HOH547 |
A | HOH557 |
A | HOH559 |
A | HOH564 |
A | HOH566 |
A | ALA226 |
A | HOH598 |
A | GLU228 |
A | GLY264 |
A | ASN265 |
A | HIS293 |
A | LYS294 |
A | ASN296 |
A | HIS297 |
site_id | AC2 |
Number of Residues | 13 |
Details | binding site for residue C7N A 402 |
Chain | Residue |
A | TRP260 |
A | ASN263 |
A | GLY264 |
A | THR266 |
A | TYR305 |
A | TYR335 |
A | GLY336 |
A | TYR337 |
A | ASP338 |
A | PRO341 |
A | PRO342 |
A | TYR353 |
A | HOH503 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue GOL A 403 |
Chain | Residue |
A | ALA261 |
A | LEU262 |
A | ASN263 |
A | GLY264 |
A | ASN265 |
A | VAL277 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue GOL A 404 |
Chain | Residue |
A | TYR217 |
A | VAL218 |
A | ALA235 |
A | GLU326 |
A | GOL405 |
A | HOH516 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue GOL A 405 |
Chain | Residue |
A | VAL218 |
A | ALA219 |
A | GOL404 |
A | HOH520 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 |
Chain | Residue | Details |
A | HIS297 | |
A | ALA226 | |
A | ASN296 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855 |
Chain | Residue | Details |
A | GLU356 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | SITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855 |
Chain | Residue | Details |
A | TYR245 | |
A | ASP256 | |
A | THR266 | |
A | LYS317 | |
A | TYR335 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 350 |
Chain | Residue | Details |
A | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
A | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
A | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |