5YLT
Crystal structure of SET7/9 in complex with a cyproheptadine derivative
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SFG A 401 |
| Chain | Residue |
| A | ILE223 |
| A | TYR335 |
| A | TRP352 |
| A | GLU356 |
| A | GLN364 |
| A | HOH512 |
| A | HOH547 |
| A | HOH557 |
| A | HOH559 |
| A | HOH564 |
| A | HOH566 |
| A | ALA226 |
| A | HOH598 |
| A | GLU228 |
| A | GLY264 |
| A | ASN265 |
| A | HIS293 |
| A | LYS294 |
| A | ASN296 |
| A | HIS297 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue C7N A 402 |
| Chain | Residue |
| A | TRP260 |
| A | ASN263 |
| A | GLY264 |
| A | THR266 |
| A | TYR305 |
| A | TYR335 |
| A | GLY336 |
| A | TYR337 |
| A | ASP338 |
| A | PRO341 |
| A | PRO342 |
| A | TYR353 |
| A | HOH503 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ALA261 |
| A | LEU262 |
| A | ASN263 |
| A | GLY264 |
| A | ASN265 |
| A | VAL277 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | TYR217 |
| A | VAL218 |
| A | ALA235 |
| A | GLU326 |
| A | GOL405 |
| A | HOH516 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | VAL218 |
| A | ALA219 |
| A | GOL404 |
| A | HOH520 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 122 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Site: {"description":"Histone H3K4 binding","evidences":[{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 350 |
| Chain | Residue | Details |
| A | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
