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5YLT

Crystal structure of SET7/9 in complex with a cyproheptadine derivative

Functional Information from GO Data
ChainGOidnamespacecontents
A0005694cellular_componentchromosome
A0006355biological_processregulation of DNA-templated transcription
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0140945molecular_functionhistone H3K4 monomethyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue SFG A 401
ChainResidue
AILE223
ATYR335
ATRP352
AGLU356
AGLN364
AHOH512
AHOH547
AHOH557
AHOH559
AHOH564
AHOH566
AALA226
AHOH598
AGLU228
AGLY264
AASN265
AHIS293
ALYS294
AASN296
AHIS297

site_idAC2
Number of Residues13
Detailsbinding site for residue C7N A 402
ChainResidue
ATRP260
AASN263
AGLY264
ATHR266
ATYR305
ATYR335
AGLY336
ATYR337
AASP338
APRO341
APRO342
ATYR353
AHOH503

site_idAC3
Number of Residues6
Detailsbinding site for residue GOL A 403
ChainResidue
AALA261
ALEU262
AASN263
AGLY264
AASN265
AVAL277

site_idAC4
Number of Residues6
Detailsbinding site for residue GOL A 404
ChainResidue
ATYR217
AVAL218
AALA235
AGLU326
AGOL405
AHOH516

site_idAC5
Number of Residues4
Detailsbinding site for residue GOL A 405
ChainResidue
AVAL218
AALA219
AGOL404
AHOH520

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855
ChainResidueDetails
AHIS297
AALA226
AASN296

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:12514135, ECO:0000269|PubMed:12540855
ChainResidueDetails
AGLU356

site_idSWS_FT_FI3
Number of Residues5
DetailsSITE: Histone H3K4 binding => ECO:0000269|PubMed:12540855
ChainResidueDetails
ATYR245
AASP256
ATHR266
ALYS317
ATYR335

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 350
ChainResidueDetails
ATYR245activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
AHIS293electrostatic stabiliser, hydrogen bond acceptor
AHIS297electrostatic stabiliser, hydrogen bond acceptor
ATYR305activator, electrostatic stabiliser, hydrogen bond acceptor
ATYR335activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

221051

PDB entries from 2024-06-12

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