5YK3
human Ragulator complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, K (m, H) | Ragulator complex protein LAMTOR3 | polymer | 124 | 13637.7 | 2 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 2 | B, L (l, G) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 2 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 3 | C (o) | Ragulator complex protein LAMTOR5 | polymer | 90 | 9535.8 | 1 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 4 | D (n) | Ragulator complex protein LAMTOR4 | polymer | 88 | 9495.8 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 5 | E (k) | Ragulator complex protein LAMTOR1 | polymer | 85 | 9516.8 | 1 | UniProt (Q6IAA8) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 6 | F (C) | Ragulator complex protein LAMTOR3 | polymer | 123 | 13490.5 | 1 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 7 | G (B) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13285.1 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 8 | H, M (E, J) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 2 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 9 | I (D) | Ragulator complex protein LAMTOR4 | polymer | 96 | 10391.8 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 10 | J, O (A, F) | Ragulator complex protein LAMTOR1 | polymer | 85 | 9573.9 | 2 | UniProt (Q6IAA8) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 11 | N (I) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
Sequence modifications
n: 6 - 92 (UniProt: Q0VGL1)
k: 79 - 161 (UniProt: Q6IAA8)
C: 2 - 123 (UniProt: Q9UHA4)
B: 4 - 125 (UniProt: Q9Y2Q5)
D: 4 - 97 (UniProt: Q0VGL1)
A, F: 78 - 161 (UniProt: Q6IAA8)
| PDB | External Database | Details |
|---|---|---|
| Ala 5 | - | expression tag |
| Ala 7 | Gln 7 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 77 | - | expression tag |
| Ala 78 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Ala 3 | - | expression tag |
| Ala 122 | Val 122 | engineered mutation |
| Ala 125 | Ser 125 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 2 | - | expression tag |
| Thr 3 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 77 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 169172.9 | |
| All* | Total formula weight | 169172.9 |
