5YK3

human Ragulator complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	m, H	Ragulator complex protein LAMTOR3	polymer	124	13637.7	2	UniProt (Q9UHA4) Pfam (PF08923) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
2	l, G	Ragulator complex protein LAMTOR2	polymer	125	13517.5	2	UniProt (Q9Y2Q5) Pfam (PF03259) In PDB	Homo sapiens (Human)	Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
3	o	Ragulator complex protein LAMTOR5	polymer	90	9535.8	1	UniProt (O43504) Pfam (PF16672) In PDB	Homo sapiens (Human)	Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
4	n	Ragulator complex protein LAMTOR4	polymer	88	9495.8	1	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
5	k	Ragulator complex protein LAMTOR1	polymer	85	9516.8	1	UniProt (Q6IAA8) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
6	C	Ragulator complex protein LAMTOR3	polymer	123	13490.5	1	UniProt (Q9UHA4) Pfam (PF08923) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
7	B	Ragulator complex protein LAMTOR2	polymer	125	13285.1	1	UniProt (Q9Y2Q5) Pfam (PF03259) In PDB	Homo sapiens (Human)	Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
8	E, J	Ragulator complex protein LAMTOR5	polymer	91	9622.9	2	UniProt (O43504) Pfam (PF16672) In PDB	Homo sapiens (Human)	Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
9	D	Ragulator complex protein LAMTOR4	polymer	96	10391.8	1	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
10	A, F	Ragulator complex protein LAMTOR1	polymer	85	9573.9	2	UniProt (Q6IAA8) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
11	I	Ragulator complex protein LAMTOR4	polymer	99	10753.2	1	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4

Sequence modifications

n: 6 - 92 (UniProt: Q0VGL1)

PDB	External Database	Details
Ala 5	-	expression tag
Ala 7	Gln 7	engineered mutation

k: 79 - 161 (UniProt: Q6IAA8)

PDB	External Database	Details
Ala 77	-	expression tag
Ala 78	-	expression tag

C: 2 - 123 (UniProt: Q9UHA4)

PDB	External Database	Details
Ala 1	-	expression tag

B: 4 - 125 (UniProt: Q9Y2Q5)

PDB	External Database	Details
Ala 1	-	expression tag
Ala 2	-	expression tag
Ala 3	-	expression tag
Ala 122	Val 122	engineered mutation
Ala 125	Ser 125	engineered mutation

D: 4 - 97 (UniProt: Q0VGL1)

PDB	External Database	Details
Ala 2	-	expression tag
Thr 3	-	expression tag

A, F: 78 - 161 (UniProt: Q6IAA8)

PDB	External Database	Details
Ala 77	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	169172.9
All*	Total formula weight	169172.9

*Water molecules are not included.