5YK3

human Ragulator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001558	biological_process	regulation of cell growth
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0005770	cellular_component	late endosome
B	0005886	cellular_component	plasma membrane
B	0008104	biological_process	protein localization
B	0010008	cellular_component	endosome membrane
B	0010761	biological_process	fibroblast migration
B	0016020	cellular_component	membrane
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0035579	cellular_component	specific granule membrane
B	0038202	biological_process	TORC1 signaling
B	0043410	biological_process	positive regulation of MAPK cascade
B	0060090	molecular_function	molecular adaptor activity
B	0070821	cellular_component	tertiary granule membrane
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	0150116	biological_process	regulation of cell-substrate junction organization
B	1902414	biological_process	protein localization to cell junction
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990877	cellular_component	FNIP-folliculin RagC/D GAP
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005768	cellular_component	endosome
C	0005770	cellular_component	late endosome
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0008104	biological_process	protein localization
C	0010008	cellular_component	endosome membrane
C	0016020	cellular_component	membrane
C	0019209	molecular_function	kinase activator activity
C	0031902	cellular_component	late endosome membrane
C	0032006	biological_process	regulation of TOR signaling
C	0032008	biological_process	positive regulation of TOR signaling
C	0035579	cellular_component	specific granule membrane
C	0038202	biological_process	TORC1 signaling
C	0043410	biological_process	positive regulation of MAPK cascade
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
C	0070821	cellular_component	tertiary granule membrane
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071986	cellular_component	Ragulator complex
C	1902414	biological_process	protein localization to cell junction
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1990877	cellular_component	FNIP-folliculin RagC/D GAP
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0008361	biological_process	regulation of cell size
D	0031902	cellular_component	late endosome membrane
D	0032008	biological_process	positive regulation of TOR signaling
D	0038202	biological_process	TORC1 signaling
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0060090	molecular_function	molecular adaptor activity
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0071986	cellular_component	Ragulator complex
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0008361	biological_process	regulation of cell size
E	0009615	biological_process	response to virus
E	0010628	biological_process	positive regulation of gene expression
E	0019079	biological_process	viral genome replication
E	0031902	cellular_component	late endosome membrane
E	0032008	biological_process	positive regulation of TOR signaling
E	0032757	biological_process	positive regulation of interleukin-8 production
E	0032991	cellular_component	protein-containing complex
E	0038202	biological_process	TORC1 signaling
E	0043066	biological_process	negative regulation of apoptotic process
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0060090	molecular_function	molecular adaptor activity
E	0061462	biological_process	protein localization to lysosome
E	0071230	biological_process	cellular response to amino acid stimulus
E	0071986	cellular_component	Ragulator complex
E	1900182	biological_process	positive regulation of protein localization to nucleus
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
E	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0001558	biological_process	regulation of cell growth
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005768	cellular_component	endosome
G	0005770	cellular_component	late endosome
G	0005886	cellular_component	plasma membrane
G	0008104	biological_process	protein localization
G	0010008	cellular_component	endosome membrane
G	0010761	biological_process	fibroblast migration
G	0016020	cellular_component	membrane
G	0031902	cellular_component	late endosome membrane
G	0032008	biological_process	positive regulation of TOR signaling
G	0035579	cellular_component	specific granule membrane
G	0038202	biological_process	TORC1 signaling
G	0043410	biological_process	positive regulation of MAPK cascade
G	0060090	molecular_function	molecular adaptor activity
G	0070821	cellular_component	tertiary granule membrane
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	0150116	biological_process	regulation of cell-substrate junction organization
G	1902414	biological_process	protein localization to cell junction
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005765	cellular_component	lysosomal membrane
H	0005768	cellular_component	endosome
H	0005770	cellular_component	late endosome
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0008104	biological_process	protein localization
H	0010008	cellular_component	endosome membrane
H	0016020	cellular_component	membrane
H	0019209	molecular_function	kinase activator activity
H	0031902	cellular_component	late endosome membrane
H	0032006	biological_process	regulation of TOR signaling
H	0032008	biological_process	positive regulation of TOR signaling
H	0035579	cellular_component	specific granule membrane
H	0038202	biological_process	TORC1 signaling
H	0043410	biological_process	positive regulation of MAPK cascade
H	0060090	molecular_function	molecular adaptor activity
H	0070062	cellular_component	extracellular exosome
H	0070821	cellular_component	tertiary granule membrane
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	1902414	biological_process	protein localization to cell junction
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1990877	cellular_component	FNIP-folliculin RagC/D GAP
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0008361	biological_process	regulation of cell size
I	0031902	cellular_component	late endosome membrane
I	0032008	biological_process	positive regulation of TOR signaling
I	0038202	biological_process	TORC1 signaling
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0060090	molecular_function	molecular adaptor activity
I	0061462	biological_process	protein localization to lysosome
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071986	cellular_component	Ragulator complex
I	1904263	biological_process	positive regulation of TORC1 signaling
I	1990877	cellular_component	FNIP-folliculin RagC/D GAP
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0008361	biological_process	regulation of cell size
J	0009615	biological_process	response to virus
J	0010628	biological_process	positive regulation of gene expression
J	0019079	biological_process	viral genome replication
J	0031902	cellular_component	late endosome membrane
J	0032008	biological_process	positive regulation of TOR signaling
J	0032757	biological_process	positive regulation of interleukin-8 production
J	0032991	cellular_component	protein-containing complex
J	0038202	biological_process	TORC1 signaling
J	0043066	biological_process	negative regulation of apoptotic process
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0060090	molecular_function	molecular adaptor activity
J	0061462	biological_process	protein localization to lysosome
J	0071230	biological_process	cellular response to amino acid stimulus
J	0071986	cellular_component	Ragulator complex
J	1900182	biological_process	positive regulation of protein localization to nucleus
J	1904263	biological_process	positive regulation of TORC1 signaling
J	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
J	1990877	cellular_component	FNIP-folliculin RagC/D GAP
l	0001558	biological_process	regulation of cell growth
l	0005085	molecular_function	guanyl-nucleotide exchange factor activity
l	0005515	molecular_function	protein binding
l	0005764	cellular_component	lysosome
l	0005765	cellular_component	lysosomal membrane
l	0005768	cellular_component	endosome
l	0005770	cellular_component	late endosome
l	0005886	cellular_component	plasma membrane
l	0008104	biological_process	protein localization
l	0010008	cellular_component	endosome membrane
l	0010761	biological_process	fibroblast migration
l	0016020	cellular_component	membrane
l	0031902	cellular_component	late endosome membrane
l	0032008	biological_process	positive regulation of TOR signaling
l	0035579	cellular_component	specific granule membrane
l	0038202	biological_process	TORC1 signaling
l	0043410	biological_process	positive regulation of MAPK cascade
l	0060090	molecular_function	molecular adaptor activity
l	0070821	cellular_component	tertiary granule membrane
l	0071230	biological_process	cellular response to amino acid stimulus
l	0071986	cellular_component	Ragulator complex
l	0150116	biological_process	regulation of cell-substrate junction organization
l	1902414	biological_process	protein localization to cell junction
l	1904263	biological_process	positive regulation of TORC1 signaling
l	1990877	cellular_component	FNIP-folliculin RagC/D GAP
m	0005085	molecular_function	guanyl-nucleotide exchange factor activity
m	0005515	molecular_function	protein binding
m	0005765	cellular_component	lysosomal membrane
m	0005768	cellular_component	endosome
m	0005770	cellular_component	late endosome
m	0005886	cellular_component	plasma membrane
m	0005925	cellular_component	focal adhesion
m	0008104	biological_process	protein localization
m	0010008	cellular_component	endosome membrane
m	0016020	cellular_component	membrane
m	0019209	molecular_function	kinase activator activity
m	0031902	cellular_component	late endosome membrane
m	0032006	biological_process	regulation of TOR signaling
m	0032008	biological_process	positive regulation of TOR signaling
m	0035579	cellular_component	specific granule membrane
m	0038202	biological_process	TORC1 signaling
m	0043410	biological_process	positive regulation of MAPK cascade
m	0060090	molecular_function	molecular adaptor activity
m	0070062	cellular_component	extracellular exosome
m	0070821	cellular_component	tertiary granule membrane
m	0071230	biological_process	cellular response to amino acid stimulus
m	0071986	cellular_component	Ragulator complex
m	1902414	biological_process	protein localization to cell junction
m	1904263	biological_process	positive regulation of TORC1 signaling
m	1990877	cellular_component	FNIP-folliculin RagC/D GAP
n	0032008	biological_process	positive regulation of TOR signaling
n	0071230	biological_process	cellular response to amino acid stimulus
n	0071986	cellular_component	Ragulator complex
o	0005085	molecular_function	guanyl-nucleotide exchange factor activity
o	0005515	molecular_function	protein binding
o	0005737	cellular_component	cytoplasm
o	0005764	cellular_component	lysosome
o	0005765	cellular_component	lysosomal membrane
o	0005829	cellular_component	cytosol
o	0008361	biological_process	regulation of cell size
o	0009615	biological_process	response to virus
o	0010628	biological_process	positive regulation of gene expression
o	0019079	biological_process	viral genome replication
o	0031902	cellular_component	late endosome membrane
o	0032008	biological_process	positive regulation of TOR signaling
o	0032757	biological_process	positive regulation of interleukin-8 production
o	0032991	cellular_component	protein-containing complex
o	0038202	biological_process	TORC1 signaling
o	0043066	biological_process	negative regulation of apoptotic process
o	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
o	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
o	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
o	0060090	molecular_function	molecular adaptor activity
o	0061462	biological_process	protein localization to lysosome
o	0071230	biological_process	cellular response to amino acid stimulus
o	0071986	cellular_component	Ragulator complex
o	1900182	biological_process	positive regulation of protein localization to nucleus
o	1904263	biological_process	positive regulation of TORC1 signaling
o	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
o	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
I	MET1
A	SER141
F	SER98
F	SER141

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
I	THR2
A	LYS104
F	LYS103
F	LYS104

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152

Chain	Residue	Details
I	SER67

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