5YJB

LSD1-CoREST in complex with 4-[5-(piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lysine-specific histone demethylase 1A	polymer	669	74333.0	1	UniProt (O60341) Pfam (PF04433) Pfam (PF01593) In PDB	Homo sapiens (Human)	BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2
2	B	REST corepressor 1	polymer	140	15850.9	1	UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) In PDB	Homo sapiens (Human)	Protein CoREST
3	A	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	1	Chemie (FAD)
4	A	4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrile	non-polymer		383.5	1	Chemie (8WC)
5	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)

Sequence modifications

A: 172 - 833 (UniProt: O60341)

PDB	External Database	Details
Gly 165	-	expression tag
Pro 166	-	expression tag
Leu 167	-	expression tag
Gly 168	-	expression tag
Ser 169	-	expression tag
His 170	-	expression tag
Met 171	-	expression tag

B: 308 - 440 (UniProt: Q9UKL0)

PDB	External Database	Details
Gly 301	-	expression tag
Ser 302	-	expression tag
Ser 303	-	expression tag
Gly 304	-	expression tag
Ser 305	-	expression tag
Ala 306	-	expression tag
Ser 307	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90184.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1353.2
All*	Total formula weight	91537.2

*Water molecules are not included.