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5YJB

LSD1-CoREST in complex with 4-[5-(piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Lysine-specific histone demethylase 1Apolymer66974333.01UniProt (O60341)
Pfam (PF04433)
Pfam (PF01593)
Homo sapiens (Human)BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2
2B
(B)
REST corepressor 1polymer14015850.91UniProt (Q9UKL0)
Pfam (PF20878)
Pfam (PF00249)
Homo sapiens (Human)Protein CoREST
3C
(A)
FLAVIN-ADENINE DINUCLEOTIDEnon-polymer785.51Chemie (FAD)
4D
(A)
4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrilenon-polymer383.51Chemie (8WC)
5E, F
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
Sequence modifications
A: 172 - 833 (UniProt: O60341)
PDBExternal DatabaseDetails
Gly 165-expression tag
Pro 166-expression tag
Leu 167-expression tag
Gly 168-expression tag
Ser 169-expression tag
His 170-expression tag
Met 171-expression tag
B: 308 - 440 (UniProt: Q9UKL0)
PDBExternal DatabaseDetails
Gly 301-expression tag
Ser 302-expression tag
Ser 303-expression tag
Gly 304-expression tag
Ser 305-expression tag
Ala 306-expression tag
Ser 307-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight90184.0
Non-Polymers*Number of molecules4
Total formula weight1353.2
All*Total formula weight91537.2
*Water molecules are not included.

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PDB entries from 2025-07-16

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