5YH2

The structure of DrFam20C1 and hFam20A complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Pseudokinase FAM20A	polymer	467	53464.2	2	UniProt (Q96MK3) Pfam (PF06702) In PDB	Homo sapiens (Human)
2	C, D	Family with sequence similarity 20, member Ca	polymer	560	64505.4	2	UniProt (E7FBB8) Pfam (PF06702) In PDB	Danio rerio (Zebrafish)	DrFam20C1
3	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, B: 63 - 529 (UniProt: Q96MK3)

PDB	External Database	Details
Lys 332	Asn 332	variant

C, D: 1 - 560 (UniProt: E7FBB8)

PDB	External Database	Details
Ala 223	Thr 223	engineered mutation
Met 421	Lys 421	engineered mutation
Asp 422	Ala 422	engineered mutation
Met 423	Leu 423	engineered mutation
Ile 425	His 425	engineered mutation
Phe 426	Tyr 426	engineered mutation
Asp 427	Ser 427	engineered mutation
Phe 428	Leu 428	engineered mutation
Leu 429	Lys 429	engineered mutation
Met 430	Thr 430	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	235939.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	236953.5

*Water molecules are not included.