5YEW
Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitofusin-1,Mitofusin-1 fusion protein | polymer | 421 | 47405.9 | 1 | UniProt (Q8IWA4) Pfam (PF00350) In PDB | Homo sapiens (Human) | Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1 |
2 | B, C | Mitofusin-1,Mitofusin-1 fusion protein | polymer | 421 | 47392.9 | 2 | UniProt (Q8IWA4) Pfam (PF00350) In PDB | Homo sapiens (Human) | Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1 |
3 | A, B, C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
4 | A, B, C | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 3 | Chemie (BEF) | |||
5 | A, B, C | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
6 | A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) |
Sequence modifications
A: 1 - 364 (UniProt: Q8IWA4)
A: 694 - 741 (UniProt: Q8IWA4)
B, C: 1 - 684 (UniProt: Q8IWA4)
B, C: 694 - 741 (UniProt: Q8IWA4)
PDB | External Database | Details |
---|---|---|
Val 138 | Thr 138 | engineered mutation |
Asn 139 | Val 139 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 685 | - | linker |
Ser 686 | - | linker |
Gly 687 | - | linker |
Ser 688 | - | linker |
Gly 689 | - | linker |
Ser 690 | - | linker |
Gly 691 | - | linker |
Gly 692 | - | linker |
Ser 693 | - | linker |
B, C: 694 - 741 (UniProt: Q8IWA4)
PDB | External Database | Details |
---|---|---|
Gly 685 | - | linker |
Ser 686 | - | linker |
Gly 687 | - | linker |
Ser 688 | - | linker |
Gly 689 | - | linker |
Ser 690 | - | linker |
Gly 691 | - | linker |
Gly 692 | - | linker |
Ser 693 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 142191.7 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1717.8 | |
All* | Total formula weight | 143909.5 |