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5YEW

Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Mitofusin-1,Mitofusin-1 fusion proteinpolymer42147405.91UniProt (Q8IWA4)
Pfam (PF00350)
Homo sapiens (Human)Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1
2B, C
(B, C)
Mitofusin-1,Mitofusin-1 fusion proteinpolymer42147392.92UniProt (Q8IWA4)
Pfam (PF00350)
Homo sapiens (Human)Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1
3D, H, L
(A, B, C)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.23Chemie (GDP)
4E, I, M
(A, B, C)
BERYLLIUM TRIFLUORIDE IONnon-polymer66.03Chemie (BEF)
5F, J, N
(A, B, C)
POTASSIUM IONnon-polymer39.13Chemie (K)
6G, K, O
(A, B, C)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
Sequence modifications
A: 1 - 364 (UniProt: Q8IWA4)
PDBExternal DatabaseDetails
Val 138Thr 138engineered mutation
Asn 139Val 139engineered mutation
A: 694 - 741 (UniProt: Q8IWA4)
PDBExternal DatabaseDetails
Gly 685-linker
Ser 686-linker
Gly 687-linker
Ser 688-linker
Gly 689-linker
Ser 690-linker
Gly 691-linker
Gly 692-linker
Ser 693-linker
B, C: 1 - 684 (UniProt: Q8IWA4)
B, C: 694 - 741 (UniProt: Q8IWA4)
PDBExternal DatabaseDetails
Gly 685-linker
Ser 686-linker
Gly 687-linker
Ser 688-linker
Gly 689-linker
Ser 690-linker
Gly 691-linker
Gly 692-linker
Ser 693-linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight142191.7
Non-Polymers*Number of molecules12
Total formula weight1717.8
All*Total formula weight143909.5
*Water molecules are not included.

238582

PDB entries from 2025-07-09

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