5YEW
Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitofusin-1,Mitofusin-1 fusion protein | polymer | 421 | 47405.9 | 1 | UniProt (Q8IWA4) Pfam (PF00350) | Homo sapiens (Human) | Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1 |
| 2 | B, C (B, C) | Mitofusin-1,Mitofusin-1 fusion protein | polymer | 421 | 47392.9 | 2 | UniProt (Q8IWA4) Pfam (PF00350) | Homo sapiens (Human) | Fzo homolog,Transmembrane GTPase MFN1,Fzo homolog,Transmembrane GTPase MFN1 |
| 3 | D, H, L (A, B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | E, I, M (A, B, C) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 3 | Chemie (BEF) | |||
| 5 | F, J, N (A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) PubChem (813) | |||
| 6 | G, K, O (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) |
Sequence modifications
A: 1 - 364 (UniProt: Q8IWA4)
A: 694 - 741 (UniProt: Q8IWA4)
B, C: 1 - 684 (UniProt: Q8IWA4)
B, C: 694 - 741 (UniProt: Q8IWA4)
| PDB | External Database | Details |
|---|---|---|
| Val 138 | Thr 138 | engineered mutation |
| Asn 139 | Val 139 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 685 | - | linker |
| Ser 686 | - | linker |
| Gly 687 | - | linker |
| Ser 688 | - | linker |
| Gly 689 | - | linker |
| Ser 690 | - | linker |
| Gly 691 | - | linker |
| Gly 692 | - | linker |
| Ser 693 | - | linker |
B, C: 694 - 741 (UniProt: Q8IWA4)
| PDB | External Database | Details |
|---|---|---|
| Gly 685 | - | linker |
| Ser 686 | - | linker |
| Gly 687 | - | linker |
| Ser 688 | - | linker |
| Gly 689 | - | linker |
| Ser 690 | - | linker |
| Gly 691 | - | linker |
| Gly 692 | - | linker |
| Ser 693 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 142191.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1717.8 | |
| All* | Total formula weight | 143909.5 |
