5YEW

Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0005741	cellular_component	mitochondrial outer membrane
A	0008053	biological_process	mitochondrial fusion
A	0016020	cellular_component	membrane
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0005741	cellular_component	mitochondrial outer membrane
B	0008053	biological_process	mitochondrial fusion
B	0016020	cellular_component	membrane
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0005741	cellular_component	mitochondrial outer membrane
C	0008053	biological_process	mitochondrial fusion
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue GDP A 801

Chain	Residue
A	SER85
A	ASN237
A	ARG238
A	ASP240
A	SER284
A	ALA285
A	LYS286
A	BEF802
A	K803
A	MG804
B	GLU245
A	GLY87
A	LYS88
A	SER89
A	SER90
A	SER103
A	GLY104
A	ILE105
A	THR109

---

site_id	AC2
Number of Residues	9
Details	binding site for residue BEF A 802

Chain	Residue
A	THR84
A	GLY106
A	HIS107
A	ILE108
A	THR109
A	GLY181
A	GDP801
A	K803
A	MG804

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 803

Chain	Residue
A	SER85
A	GLY104
A	GLY106
A	GDP801
A	BEF802

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 804

Chain	Residue
A	SER89
A	THR109
A	ASP178
A	GDP801
A	BEF802

---

site_id	AC5
Number of Residues	20
Details	binding site for residue GDP B 801

Chain	Residue
A	GLU245
B	ARG83
B	SER85
B	SER86
B	GLY87
B	LYS88
B	SER89
B	SER90
B	SER103
B	GLY104
B	THR109
B	ASN237
B	ARG238
B	ASP240
B	SER284
B	ALA285
B	LYS286
B	BEF802
B	K803
B	MG804

---

site_id	AC6
Number of Residues	9
Details	binding site for residue BEF B 802

Chain	Residue
B	THR84
B	LYS88
B	GLY106
B	HIS107
B	ILE108
B	THR109
B	GLY181
B	GDP801
B	K803

---

site_id	AC7
Number of Residues	5
Details	binding site for residue K B 803

Chain	Residue
B	SER85
B	GLY104
B	GLY106
B	GDP801
B	BEF802

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 804

Chain	Residue
B	SER89
B	THR109
B	GDP801

---

site_id	AC9
Number of Residues	19
Details	binding site for residue GDP C 801

Chain	Residue
C	SER85
C	SER86
C	GLY87
C	LYS88
C	SER89
C	SER90
C	SER103
C	GLY104
C	ILE105
C	ASN237
C	ARG238
C	ASP240
C	GLU245
C	SER284
C	ALA285
C	LYS286
C	BEF802
C	K803
C	MG804

---

site_id	AD1
Number of Residues	10
Details	binding site for residue BEF C 802

Chain	Residue
C	PRO180
C	GLY181
C	GDP801
C	K803
C	MG804
C	THR84
C	LYS88
C	HIS107
C	ILE108
C	THR109

---

site_id	AD2
Number of Residues	5
Details	binding site for residue K C 803

Chain	Residue
C	SER85
C	GLY104
C	GLY106
C	GDP801
C	BEF802

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MG C 804

Chain	Residue
C	SER89
C	THR109
C	GDP801
C	BEF802

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	244
Details	Region: {"description":"Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions","evidences":[{"source":"PubMed","id":"16959974","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27920125","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27920125","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27920125","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28114303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GOF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27920125","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GNS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---