5YAK

The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Iodotyrosine deiodinase 1	polymer	264	30538.0	6	UniProt (Q6PHW0) Pfam (PF00881)	Homo sapiens (Human)	IYD-1,Iodotyrosine dehalogenase 1
2	G, I, K, M, O... (A, B, C, D, E...)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	6	Chemie (FMN)
3	H, J, L, N, P... (A, B, C, D, E...)	3-FLUOROTYROSINE	non-polymer		199.2	6	Chemie (YOF)
4	S, T, U, V, W... (A, B, C, D, E...)	water	water		18.0	297	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 32 - 289 (UniProt: Q6PHW0)

PDB	External Database	Details
Ala 239	Thr 239	engineered mutation
His 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	183227.7
Non-Polymers*	Number of molecules	12
	Total formula weight	3933.1
All*	Total formula weight	187160.8

*Water molecules are not included.