5Y6L
A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Methionine--tRNA ligase, cytoplasmic | polymer | 232 | 25956.4 | 1 | UniProt (P56192) Pfam (PF18485) Pfam (PF00043) In PDB | Homo sapiens (Human) | Methionyl-tRNA synthetase,MetRS |
2 | B | Eukaryotic translation elongation factor 1 epsilon-1 | polymer | 186 | 21226.0 | 1 | UniProt (O43324) Pfam (PF21972) In PDB | Homo sapiens (Human) | Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3,Elongation factor p18,Multisynthase complex auxiliary component p18 |
3 | C | Bifunctional glutamate/proline--tRNA ligase | polymer | 175 | 19310.7 | 1 | UniProt (P07814) Pfam (PF21972) In PDB | Homo sapiens (Human) | Bifunctional aminoacyl-tRNA synthetase,Cell proliferation-inducing gene 32 protein,Glutamatyl-prolyl-tRNA synthetase |
4 | D | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | polymer | 240 | 26790.9 | 1 | UniProt (Q13155) Pfam (PF18569) Pfam (PF00043) In PDB | Homo sapiens (Human) | Multisynthase complex auxiliary component p38,Protein JTV-1 |
5 | E | Aspartate--tRNA ligase, cytoplasmic | polymer | 521 | 59384.4 | 1 | UniProt (P14868) Pfam (PF01336) Pfam (PF00152) In PDB | Homo sapiens (Human) | Aspartyl-tRNA synthetase,AspRS,Cell proliferation-inducing gene 40 protein |
6 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
7 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 1 - 224 (UniProt: P56192)
B: 1 - 174 (UniProt: O43324)
C: 1 - 175 (UniProt: P07814)
D: 90 - 320 (UniProt: Q13155)
E: 1 - 501 (UniProt: P14868)
PDB | External Database | Details |
---|---|---|
Arg 171 | Ser 171 | engineered mutation |
Leu 225 | - | expression tag |
Glu 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
His 231 | - | expression tag |
His 232 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 147 | Cys 147 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 92 | Cys 92 | engineered mutation |
Ser 105 | Cys 105 | engineered mutation |
Ser 123 | Cys 123 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 89 | - | initiating methionine |
Leu 321 | - | expression tag |
Glu 322 | - | expression tag |
His 323 | - | expression tag |
His 324 | - | expression tag |
His 325 | - | expression tag |
His 326 | - | expression tag |
His 327 | - | expression tag |
His 328 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 152668.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 189.9 | |
All* | Total formula weight | 152858.4 |