5Y6L

A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
B	0043065	biological_process	positive regulation of apoptotic process
B	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
B	1990830	biological_process	cellular response to leukemia inhibitory factor
B	2000774	biological_process	positive regulation of cellular senescence
B	2001235	biological_process	positive regulation of apoptotic signaling pathway
C	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
C	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
D	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
E	0000166	molecular_function	nucleotide binding
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0004046	molecular_function	aminoacylase activity
E	0004812	molecular_function	aminoacyl-tRNA ligase activity
E	0004815	molecular_function	aspartate-tRNA ligase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006412	biological_process	translation
E	0006418	biological_process	tRNA aminoacylation for protein translation
E	0006422	biological_process	aspartyl-tRNA aminoacylation
E	0016020	cellular_component	membrane
E	0017101	cellular_component	aminoacyl-tRNA synthetase multienzyme complex
E	0045202	cellular_component	synapse
E	0065003	biological_process	protein-containing complex assembly
E	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PO4 A 301

Chain	Residue
A	HIS123
A	HIS126
A	ARG130

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 B 201

Chain	Residue
B	HIS148
B	HIS151
B	TYR152
C	ASN115
C	SER116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
E	GLU229
E	ARG273
E	ARG281
E	GLU424
E	SER427
E	ARG431
E	GLY472

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	THR52

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS74
E	LYS374

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER249

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000255

Chain	Residue	Details
E	THR500

---