5Y5E
Crystal structure of phospholipase A2 with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Group IIE secretory phospholipase A2 | polymer | 123 | 13929.1 | 1 | UniProt (Q9NZK7) Pfam (PF00068) In PDB | Homo sapiens (Human) | sPLA2-IIE,Phosphatidylcholine 2-acylhydrolase 2E |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | A | 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic acid | non-polymer | 434.4 | 1 | Chemie (7W3) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | A | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 7 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 1 - 123 (UniProt: Q9NZK7)
| PDB | External Database | Details |
|---|---|---|
| Gly 21 | Asn 40 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13929.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1049.1 | |
| All* | Total formula weight | 14978.2 |
