5Y3A

Crystal structure of Ragulator complex (p18 49-161)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F	Ragulator complex protein LAMTOR1	polymer	112	12348.9	2	UniProt (Q6IAA8) Pfam (PF15454) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
2	B, G	Ragulator complex protein LAMTOR2	polymer	127	13719.7	2	UniProt (Q9Y2Q5) Pfam (PF03259) In PDB	Homo sapiens (Human)	Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
3	C, H	Ragulator complex protein LAMTOR3	polymer	124	13637.7	2	UniProt (Q9UHA4) Pfam (PF08923) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
4	D, I	Ragulator complex protein LAMTOR4	polymer	101	10941.5	2	UniProt (Q0VGL1) In PDB	Homo sapiens (Human)	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
5	E, J	Ragulator complex protein LAMTOR5	polymer	93	9825.2	2	UniProt (O43504) Pfam (PF16672) In PDB	Homo sapiens (Human)	Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5
6	A, E, F, I, J	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
7		water	water		18.0	12	Chemie (HOH)

Sequence modifications

B, G: 1 - 125 (UniProt: Q9Y2Q5)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag

D, I: 1 - 99 (UniProt: Q0VGL1)

PDB	External Database	Details
Met -1	-	expression tag
Gly 0	-	expression tag

E, J: 83 - 173 (UniProt: O43504)

PDB	External Database	Details
Met 81	-	expression tag
Ala 82	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	120946.0
Non-Polymers*	Number of molecules	8
	Total formula weight	768.5
All*	Total formula weight	121714.5

*Water molecules are not included.