5Y0Z
Human SIRT2 in complex with a specific inhibitor, NPD11033
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 293 | 33201.2 | 2 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (Human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | (1~{R},9~{S})-11-[(2~{R})-3-[2,4-bis(2-methylbutan-2-yl)phenoxy]-2-oxidanyl-propyl]-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one | non-polymer | 480.7 | 2 | Chemie (8K9) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, B: 52 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| - | Gln 292 | deletion |
| - | Ser 293 | deletion |
| - | Asp 294 | deletion |
| - | Pro 295 | deletion |
| - | Phe 296 | deletion |
| - | Leu 297 | deletion |
| - | Gly 298 | deletion |
| - | Met 299 | deletion |
| - | Ile 300 | deletion |
| - | Met 301 | deletion |
| - | Gly 302 | deletion |
| - | Leu 303 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66402.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1092.2 | |
| All* | Total formula weight | 67494.6 |
