5Y0Z
Human SIRT2 in complex with a specific inhibitor, NPD11033
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
A | 0051287 | molecular_function | NAD binding |
A | 0070403 | molecular_function | NAD+ binding |
B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
B | 0051287 | molecular_function | NAD binding |
B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | CYS195 |
A | CYS200 |
A | CYS221 |
A | CYS224 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue 8K9 A 502 |
Chain | Residue |
A | ILE169 |
A | HIS187 |
A | PHE190 |
A | VAL233 |
A | PHE235 |
A | PHE96 |
A | ARG97 |
A | PHE119 |
A | TYR139 |
A | PRO140 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | CYS195 |
B | CYS200 |
B | CYS221 |
B | CYS224 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue 8K9 B 502 |
Chain | Residue |
B | PHE96 |
B | ARG97 |
B | PHE119 |
B | PHE131 |
B | ALA135 |
B | PRO140 |
B | ILE169 |
B | HIS187 |
B | PHE190 |
B | VAL233 |
B | PHE235 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
Chain | Residue | Details |
A | HIS187 | |
B | HIS187 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25672491, ECO:0007744|PDB:4RMG |
Chain | Residue | Details |
A | ALA85 | |
B | THR262 | |
B | ASN286 | |
B | GLY336 | |
A | ASP95 | |
A | GLN167 | |
A | THR262 | |
A | ASN286 | |
A | GLY336 | |
B | ALA85 | |
B | ASP95 | |
B | GLN167 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11427894, ECO:0000269|PubMed:23454361, ECO:0000269|PubMed:24389023, ECO:0000269|PubMed:25672491, ECO:0000269|PubMed:25704306, ECO:0007744|PDB:4R8M |
Chain | Residue | Details |
A | CYS195 | |
A | CYS200 | |
A | CYS221 | |
A | CYS224 | |
B | CYS195 | |
B | CYS200 | |
B | CYS221 | |
B | CYS224 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RJQ4 |
Chain | Residue | Details |
A | SER53 | |
A | SER100 | |
A | SER207 | |
B | SER53 | |
B | SER100 | |
B | SER207 |