5XTD
Cryo-EM structure of human respiratory complex I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 431 | 47323.9 | 1 | UniProt (P49821) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Homo sapiens (Human) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20314.0 | 1 | UniProt (O00217) Pfam (PF12838) | Homo sapiens (Human) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17887.9 | 1 | UniProt (O75251) Pfam (PF01058) | Homo sapiens (Human) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 4 | D (E) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 113 | 13758.1 | 1 | UniProt (P56556) Pfam (PF13233) | Homo sapiens (Human) | Complex I-B14,CI-B14,LYR motif-containing protein 6,NADH-ubiquinone oxidoreductase B14 subunit |
| 5 | E (F) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 83 | 9535.9 | 1 | UniProt (O43678) Pfam (PF05047) | Homo sapiens (Human) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 6 | F, V (G, X) | Acyl carrier protein, mitochondrial | polymer | 85 | 9845.2 | 2 | UniProt (O14561) Pfam (PF00550) | Homo sapiens (Human) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 7 | G (H) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 112 | 13119.2 | 1 | UniProt (Q16718) Pfam (PF04716) | Homo sapiens (Human) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 8 | H (I) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 110 | 12282.1 | 1 | UniProt (O95182) Pfam (PF07347) | Homo sapiens (Human) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 9 | I (J) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 337 | 38387.6 | 1 | UniProt (Q16795) Pfam (PF01370) | Homo sapiens (Human) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 10 | J (K) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 33 | 3900.3 | 1 | UniProt (P56181) Pfam (PF15880) | Homo sapiens (Human) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit,Renal carcinoma antigen NY-REN-4 |
| 11 | K (L) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 118 | 13721.6 | 1 | UniProt (O43181) Pfam (PF04800) | Homo sapiens (Human) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 12 | L (M) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 687 | 75471.5 | 1 | UniProt (P28331) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) | Homo sapiens (Human) | Complex I-75kD,CI-75kD |
| 13 | M (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 143 | 16880.1 | 1 | UniProt (Q9UI09) Pfam (PF05071) | Homo sapiens (Human) | 13 kDa differentiation-associated protein,Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 14 | N (O) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 212 | 23430.9 | 1 | UniProt (P19404) Pfam (PF01257) | Homo sapiens (Human) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 15 | O (P) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 208 | 24432.7 | 1 | UniProt (O75489) Pfam (PF00329) | Homo sapiens (Human) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 16 | P (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 430 | 49236.5 | 1 | UniProt (O75306) Pfam (PF00346) | Homo sapiens (Human) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 17 | Q (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8084.4 | 1 | UniProt (O15239) Pfam (PF15879) | Homo sapiens (Human) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 18 | R (T) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 95 | 10578.8 | 1 | UniProt (O75380) Pfam (PF10276) | Homo sapiens (Human) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 19 | S (U) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 83 | 9156.6 | 1 | UniProt (O95167) Pfam (PF14987) | Homo sapiens (Human) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 20 | T (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14736.9 | 1 | UniProt (Q86Y39) | Homo sapiens (Human) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 21 | U (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 138 | 16132.6 | 1 | UniProt (Q9P0J0) Pfam (PF06212) | Homo sapiens (Human) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 22 | W (Y) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 59 | 7468.3 | 1 | UniProt (O95178) Pfam (PF14813) | Homo sapiens (Human) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 23 | X (Z) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 80 | 9261.6 | 1 | UniProt (O43676) Pfam (PF08122) | Homo sapiens (Human) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 24 | Y (a) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 138 | 16573.2 | 1 | UniProt (O43674) Pfam (PF09781) | Homo sapiens (Human) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 25 | Z (b) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15517.2 | 1 | UniProt (O95139) Pfam (PF09782) | Homo sapiens (Human) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 26 | AA (c) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 153 | 18267.6 | 1 | UniProt (O95169) Pfam (PF05821) | Homo sapiens (Human) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 27 | BA (d) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 171 | 20721.7 | 1 | UniProt (O96000) Pfam (PF10249) | Homo sapiens (Human) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 28 | CA (e) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 97 | 11494.9 | 1 | UniProt (Q9NX14) Pfam (PF10183) | Homo sapiens (Human) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 17.3,p17.3 |
| 29 | DA (f) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 47 | 5704.6 | 1 | UniProt (O43677) Pfam (PF15088) | Homo sapiens (Human) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 30 | EA (g) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 119 | 14209.5 | 1 | UniProt (O95298) Pfam (PF06374) | Homo sapiens (Human) | Complex I-B14.5b,CI-B14.5b,Human lung cancer oncogene 1 protein,HLC-1,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 31 | FA (h) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 104 | 12314.3 | 1 | UniProt (O43920) Pfam (PF10200) | Homo sapiens (Human) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 32 | GA (i) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39007.7 | 1 | UniProt (Q4GRX1) Pfam (PF00361) Pfam (PF06444) UniProt (by SIFTS) (P03891) | Homo sapiens (Human) | |
| 33 | HA (j) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13147.9 | 1 | UniProt (B9EE38) Pfam (PF00507) UniProt (by SIFTS) (P03897) | Homo sapiens (Human) | |
| 34 | IA (k) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 97 | 10702.1 | 1 | UniProt (V9JN72) Pfam (PF00420) UniProt (by SIFTS) (P03901) | Homo sapiens (Human) | |
| 35 | JA (l) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 603 | 67096.0 | 1 | UniProt (X5BVZ3) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) UniProt (by SIFTS) (P03915) | Homo sapiens (Human) | |
| 36 | KA (m) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 174 | 18661.0 | 1 | UniProt (Q8HAX7) Pfam (PF00499) UniProt (by SIFTS) (P03923) | Homo sapiens (Human) | |
| 37 | LA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 56 | 6741.9 | 1 | UniProt (O75438) Pfam (PF08040) | Homo sapiens (Human) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 38 | MA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 15100.4 | 1 | UniProt (O95168) Pfam (PF07225) | Homo sapiens (Human) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 39 | NA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 172 | 21189.1 | 1 | UniProt (Q9Y6M9) Pfam (PF05347) | Homo sapiens (Human) | Complex I-B22,CI-B22,LYR motif-containing protein 3,NADH-ubiquinone oxidoreductase B22 subunit |
| 40 | OA (r) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51689.7 | 1 | UniProt (B2XJG5) Pfam (PF01059) Pfam (PF00361) UniProt (by SIFTS) (P03905) | Homo sapiens (Human) | |
| 41 | PA (s) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35621.2 | 1 | UniProt (H9PGF0) Pfam (PF00146) UniProt (by SIFTS) (P03886) | Homo sapiens (Human) | |
| 42 | QA (u) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 169 | 19853.7 | 1 | UniProt (P51970) Pfam (PF06747) | Homo sapiens (Human) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 43 | RA (v) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16435.0 | 1 | UniProt (P17568) Pfam (PF05676) | Homo sapiens (Human) | Cell adhesion protein SQM1,Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 44 | SA (w) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 37200.3 | 1 | UniProt (O95299) Pfam (PF01712) | Homo sapiens (Human) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 45 | BB, CB, TA, VA, WA... (M, A, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 46 | UA (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 47 | FB, IB, KB, LB, MB... (U, V, b, g, r...) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 9 | Chemie (PLX) | |||
| 48 | UB, ZA (p, E) | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate | non-polymer | 540.7 | 2 | Chemie (8Q1) | |||
| 49 | AB (J) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 50 | DB, EB (M, O) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 51 | GB, OB, RB, SB, TB (V, i, l, n) | CARDIOLIPIN | non-polymer | 1464.0 | 5 | Chemie (CDL) | |||
| 52 | HB, JB, PB, QB (V, W, l) | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 749.1 | 4 | Chemie (PEE) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 942040.8 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 21965.2 | |
| All* | Total formula weight | 964006.0 |
