5XTD

Cryo-EM structure of human respiratory complex I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0009060	biological_process	aerobic respiration
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0022904	biological_process	respiratory electron transport chain
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0045271	cellular_component	respiratory chain complex I
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	1902600	biological_process	proton transmembrane transport
B	0016020	cellular_component	membrane
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0048038	molecular_function	quinone binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0045271	cellular_component	respiratory chain complex I
G	0006633	biological_process	fatty acid biosynthetic process
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0022904	biological_process	respiratory electron transport chain
H	0032991	cellular_component	protein-containing complex
H	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0022904	biological_process	respiratory electron transport chain
I	0042773	biological_process	ATP synthesis coupled electron transport
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045271	cellular_component	respiratory chain complex I
I	1902600	biological_process	proton transmembrane transport
K	0005739	cellular_component	mitochondrion
K	0045271	cellular_component	respiratory chain complex I
L	0022900	biological_process	electron transport chain
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009055	molecular_function	electron transfer activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0022904	biological_process	respiratory electron transport chain
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	1902600	biological_process	proton transmembrane transport
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0022904	biological_process	respiratory electron transport chain
N	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	1902600	biological_process	proton transmembrane transport
O	0016491	molecular_function	oxidoreductase activity
P	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005759	cellular_component	mitochondrial matrix
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009055	molecular_function	electron transfer activity
Q	0009060	biological_process	aerobic respiration
Q	0016491	molecular_function	oxidoreductase activity
Q	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0022904	biological_process	respiratory electron transport chain
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0045271	cellular_component	respiratory chain complex I
Q	0046872	molecular_function	metal ion binding
Q	0048038	molecular_function	quinone binding
Q	0051287	molecular_function	NAD binding
Q	0051536	molecular_function	iron-sulfur cluster binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0061351	biological_process	neural precursor cell proliferation
Q	0071453	biological_process	cellular response to oxygen levels
Q	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0022904	biological_process	respiratory electron transport chain
S	0031966	cellular_component	mitochondrial membrane
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	1902600	biological_process	proton transmembrane transport
T	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009060	biological_process	aerobic respiration
U	0022904	biological_process	respiratory electron transport chain
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0045271	cellular_component	respiratory chain complex I
U	1902600	biological_process	proton transmembrane transport
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V	0009060	biological_process	aerobic respiration
V	0022904	biological_process	respiratory electron transport chain
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0045271	cellular_component	respiratory chain complex I
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006915	biological_process	apoptotic process
W	0009060	biological_process	aerobic respiration
W	0022904	biological_process	respiratory electron transport chain
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0035458	biological_process	cellular response to interferon-beta
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045039	biological_process	protein insertion into mitochondrial inner membrane
W	0045271	cellular_component	respiratory chain complex I
W	0045732	biological_process	positive regulation of protein catabolic process
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0061133	molecular_function	endopeptidase activator activity
W	0071300	biological_process	cellular response to retinoic acid
W	0098803	cellular_component	respiratory chain complex
W	1900119	biological_process	positive regulation of execution phase of apoptosis
X	0006633	biological_process	fatty acid biosynthetic process
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0045271	cellular_component	respiratory chain complex I
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
b	0009060	biological_process	aerobic respiration
b	0022904	biological_process	respiratory electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0045271	cellular_component	respiratory chain complex I
b	1902600	biological_process	proton transmembrane transport
c	0005739	cellular_component	mitochondrion
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0005515	molecular_function	protein binding
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
d	0009060	biological_process	aerobic respiration
d	0022904	biological_process	respiratory electron transport chain
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1902600	biological_process	proton transmembrane transport
f	0005739	cellular_component	mitochondrion
f	0045271	cellular_component	respiratory chain complex I
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005886	cellular_component	plasma membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
g	0009060	biological_process	aerobic respiration
g	0010918	biological_process	positive regulation of mitochondrial membrane potential
g	0022904	biological_process	respiratory electron transport chain
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0035577	cellular_component	azurophil granule membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
g	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
g	1902600	biological_process	proton transmembrane transport
g	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
g	2001171	biological_process	positive regulation of ATP biosynthetic process
h	0005515	molecular_function	protein binding
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005758	cellular_component	mitochondrial intermembrane space
h	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
h	0009060	biological_process	aerobic respiration
h	0022904	biological_process	respiratory electron transport chain
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
h	1902600	biological_process	proton transmembrane transport
i	0001666	biological_process	response to hypoxia
i	0005515	molecular_function	protein binding
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0009060	biological_process	aerobic respiration
i	0019901	molecular_function	protein kinase binding
i	0022904	biological_process	respiratory electron transport chain
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0035255	molecular_function	ionotropic glutamate receptor binding
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
i	1902600	biological_process	proton transmembrane transport
j	0005515	molecular_function	protein binding
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
j	0006979	biological_process	response to oxidative stress
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0009060	biological_process	aerobic respiration
j	0009642	biological_process	response to light intensity
j	0009725	biological_process	response to hormone
j	0022904	biological_process	respiratory electron transport chain
j	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
j	0045271	cellular_component	respiratory chain complex I
j	0071385	biological_process	cellular response to glucocorticoid stimulus
j	1902600	biological_process	proton transmembrane transport
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0009060	biological_process	aerobic respiration
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0022904	biological_process	respiratory electron transport chain
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
k	0045271	cellular_component	respiratory chain complex I
k	1902600	biological_process	proton transmembrane transport
l	0001666	biological_process	response to hypoxia
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0009060	biological_process	aerobic respiration
l	0015990	biological_process	electron transport coupled proton transport
l	0022904	biological_process	respiratory electron transport chain
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042542	biological_process	response to hydrogen peroxide
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
m	0009060	biological_process	aerobic respiration
m	0022904	biological_process	respiratory electron transport chain
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
m	0045271	cellular_component	respiratory chain complex I
m	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0009060	biological_process	aerobic respiration
n	0022904	biological_process	respiratory electron transport chain
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
n	1902600	biological_process	proton transmembrane transport
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0022904	biological_process	respiratory electron transport chain
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0007605	biological_process	sensory perception of sound
p	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
p	0009060	biological_process	aerobic respiration
p	0022904	biological_process	respiratory electron transport chain
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
p	1902600	biological_process	proton transmembrane transport
r	0001666	biological_process	response to hypoxia
r	0001701	biological_process	in utero embryonic development
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0021549	biological_process	cerebellum development
r	0022904	biological_process	respiratory electron transport chain
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0035094	biological_process	response to nicotine
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
r	0045471	biological_process	response to ethanol
r	0048039	molecular_function	ubiquinone binding
s	0001666	biological_process	response to hypoxia
s	0003954	molecular_function	NADH dehydrogenase activity
s	0005515	molecular_function	protein binding
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0009060	biological_process	aerobic respiration
s	0009410	biological_process	response to xenobiotic stimulus
s	0016020	cellular_component	membrane
s	0022904	biological_process	respiratory electron transport chain
s	0030425	cellular_component	dendrite
s	0031966	cellular_component	mitochondrial membrane
s	0032981	biological_process	mitochondrial respiratory chain complex I assembly
s	0033194	biological_process	response to hydroperoxide
s	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
s	0043025	cellular_component	neuronal cell body
s	0045271	cellular_component	respiratory chain complex I
s	1902600	biological_process	proton transmembrane transport
u	0005515	molecular_function	protein binding
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005758	cellular_component	mitochondrial intermembrane space
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
u	0009060	biological_process	aerobic respiration
u	0022904	biological_process	respiratory electron transport chain
u	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
u	0044877	molecular_function	protein-containing complex binding
u	0045271	cellular_component	respiratory chain complex I
u	1902600	biological_process	proton transmembrane transport
v	0005515	molecular_function	protein binding
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0005758	cellular_component	mitochondrial intermembrane space
v	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
v	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
v	0009060	biological_process	aerobic respiration
v	0022904	biological_process	respiratory electron transport chain
v	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
v	0045271	cellular_component	respiratory chain complex I
v	1902600	biological_process	proton transmembrane transport
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
w	0009060	biological_process	aerobic respiration
w	0022904	biological_process	respiratory electron transport chain
w	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
w	0045271	cellular_component	respiratory chain complex I
w	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SF4 A 501

Chain	Residue
A	ILE205
A	CYS425
A	PRO223
A	SER378
A	CYS379
A	GLN381
A	CYS382
A	CYS385
A	THR423
A	ILE424

---

site_id	AC2
Number of Residues	11
Details	binding site for residue FMN A 502

Chain	Residue
A	GLY87
A	ARG88
A	GLY89
A	ASN116
A	GLU119
A	GLY207
A	GLU208
A	GLU209
A	ALA243
A	ASN244
A	ALA426

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 B 301

Chain	Residue
B	CYS111
B	ALA113
B	CYS114
B	LYS115
B	CYS117
B	CYS160
B	ALA164
B	ILE165

---

site_id	AC4
Number of Residues	11
Details	binding site for residue SF4 B 302

Chain	Residue
B	HIS99
B	CYS121
B	PRO122
B	CYS150
B	ILE151
B	TYR152
B	CYS153
B	GLY154
B	PHE155
B	CYS156
B	GLU167

---

site_id	AC5
Number of Residues	12
Details	binding site for residue PLX B 303

Chain	Residue
B	THR58
B	TRP61
B	PHE65
Q	ARG266
Q	ASN270
s	MET183
s	MET184
s	ILE273
s	TYR277
s	PHE280
s	LEU288
s	ASN292

---

site_id	AC6
Number of Residues	9
Details	binding site for residue SF4 C 301

Chain	Residue
C	ALA87
C	CYS88
C	CYS89
C	GLY151
C	SER152
C	CYS153
C	CYS183
C	PRO184
Q	HIS223

---

site_id	AC7
Number of Residues	9
Details	binding site for residue 8Q1 E 201

Chain	Residue
E	MET25
E	TRP39
E	MET66
E	PHE67
E	ASN70
E	VAL79
E	LEU82
E	VAL83
G	SER112

---

site_id	AC8
Number of Residues	18
Details	binding site for residue NDP J 401

Chain	Residue
J	GLY60
J	THR62
J	GLY63
J	PHE64
J	LEU65
J	ALA110
J	LEU129
J	ILE130
J	GLY131
J	ARG132
J	PHE145
J	SER168
J	HIS169
J	TYR180
J	LYS184
J	PRO203
J	ILE206
J	ARG212

---

site_id	AC9
Number of Residues	9
Details	binding site for residue SF4 M 801

Chain	Residue
M	HIS124
M	ASP127
M	CYS128
M	CYS131
M	GLY134
M	CYS137
M	GLN140
M	VAL228
M	GLY229

---

site_id	AD1
Number of Residues	9
Details	binding site for residue SF4 M 802

Chain	Residue
M	CYS179
M	CYS182
M	CYS226
M	PRO227
M	VAL228
M	ALA230
M	LEU231
M	CYS176
M	ILE177

---

site_id	AD2
Number of Residues	9
Details	binding site for residue FES M 803

Chain	Residue
M	ARG62
M	CYS64
M	TYR65
M	ALA72
M	ASN74
M	CYS75
M	MET77
M	CYS78
M	CYS92

---

site_id	AD3
Number of Residues	9
Details	binding site for residue FES O 301

Chain	Residue
O	CYS135
O	THR137
O	PRO139
O	CYS140
O	CYS176
O	LEU177
O	GLY178
O	ALA179
O	CYS180

---

site_id	AD4
Number of Residues	8
Details	binding site for residue PLX U 101

Chain	Residue
U	ALA12
U	GLU16
U	PHE23
U	GLY26
j	TRP106
j	LEU107
j	ASP112
s	PRO295

---

site_id	AD5
Number of Residues	11
Details	binding site for residue CDL V 201

Chain	Residue
V	THR35
V	TYR39
V	ARG40
V	ASN44
V	TYR59
V	THR62
i	PRO110
i	HIS112
i	LEU160
l	ILE576
l	THR577

---

site_id	AD6
Number of Residues	5
Details	binding site for residue PEE V 202

Chain	Residue
V	TRP133
i	LEU276
i	ILE277
i	THR284
l	PEE701

---

site_id	AD7
Number of Residues	7
Details	binding site for residue PLX V 203

Chain	Residue
V	TYR108
V	GLY109
V	ALA112
l	LEU553
o	PRO82
o	ALA91
o	PHE95

---

site_id	AD8
Number of Residues	12
Details	binding site for residue PEE W 201

Chain	Residue
S	HIS40
W	PHE140
W	MET141
W	TYR143
W	THR144
j	LEU7
m	VAL37
m	LEU44
m	PHE56
s	LEU77
s	LEU98
s	PHE104

---

site_id	AD9
Number of Residues	9
Details	binding site for residue PLX b 201

Chain	Residue
a	THR87
a	ASN90
a	GLN95
b	TYR84
b	TYR88
b	GLU92
d	ARG43
e	TYR108
r	PLX502

---

site_id	AE1
Number of Residues	10
Details	binding site for residue PLX g 201

Chain	Residue
g	PRO9
g	LEU10
g	PHE12
g	ARG77
h	PRO2
h	PHE3
i	THR132
i	TRP133
i	TYR143
i	ILE346

---

site_id	AE2
Number of Residues	4
Details	binding site for residue PLX g 202

Chain	Residue
f	HIS62
g	LEU25
g	PHE35
g	PHE68

---

site_id	AE3
Number of Residues	10
Details	binding site for residue PLX g 203

Chain	Residue
f	LYS43
f	THR47
g	ARG48
g	ARG50
g	ARG59
g	LEU62
g	TYR63
g	PHE67
i	PRO324
i	PHE325

---

site_id	AE4
Number of Residues	9
Details	binding site for residue CDL i 401

Chain	Residue
g	LEU46
i	THR238
i	TRP239
i	THR241
i	PRO242
i	LEU243
r	TRP16
r	SER90
r	LYS93

---

site_id	AE5
Number of Residues	11
Details	binding site for residue PEE l 701

Chain	Residue
Q	GLN46
Q	TYR53
V	PEE202
i	ILE285
i	LEU288
i	TYR291
i	ARG295
l	SER567
l	GLN570
l	ILE571
r	VAL155

---

site_id	AE6
Number of Residues	11
Details	binding site for residue PEE l 702

Chain	Residue
c	ARG116
l	THR166
l	GLN170
l	LEU173
l	TYR174
l	MET533
l	HIS534
l	ILE537
l	PRO538
l	GLY541
l	THR544

---

site_id	AE7
Number of Residues	13
Details	binding site for residue CDL l 703

Chain	Residue
a	LEU68
a	LEU71
a	ARG72
l	THR22
l	LEU23
l	PRO26
l	LYS28
l	GLN116
l	LYS119
l	TYR120
r	LEU354
r	PHE357
r	LEU360

---

site_id	AE8
Number of Residues	6
Details	binding site for residue CDL l 704

Chain	Residue
c	ASP148
l	SER209
l	THR211
l	LEU214
l	LEU272
r	ASN390

---

site_id	AE9
Number of Residues	11
Details	binding site for residue CDL n 101

Chain	Residue
g	THR26
g	LEU31
g	TYR32
i	PRO338
n	TYR26
n	LYS30
n	ARG34
r	THR55
r	PHE121
u	PHE169
u	TRP170

---

site_id	AF1
Number of Residues	15
Details	binding site for residue 8Q1 p 201

Chain	Residue
X	ASP111
X	SER112
X	LEU113
p	GLN13
p	ALA23
p	HIS26
p	LEU27
p	MET44
p	ARG47
p	PHE48
p	HIS51
p	LYS52
p	GLU54
p	ALA60
p	ARG74

---

site_id	AF2
Number of Residues	7
Details	binding site for residue PLX r 501

Chain	Residue
o	TYR102
r	ASN188
r	TRP190
r	ASN193
r	HIS256
r	MET257
r	PRO260

---

site_id	AF3
Number of Residues	8
Details	binding site for residue PLX r 502

Chain	Residue
b	PLX201
e	ALA107
e	TYR108
l	ILE16
r	LEU68
r	TRP71
r	LEU447
r	ASN450

---

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
B	CYS111-PRO122
B	CYS150-PRO161

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
A	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
A	GLU377-GLY388

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
G	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
G	ASP132-ILE144

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFaDAMKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP

Chain	Residue	Details
C	GLY169-PRO185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Hydroxyarginine","evidences":[{"source":"PubMed","id":"27226634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ75","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	150
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CR21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31664822","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ODD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	128
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z1P6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20433953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91VD9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04394","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D6J6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"22823520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91WD5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine","evidences":[{"source":"PubMed","id":"24089531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24838397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1313
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52503","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q02371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q8HXG6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	42
Details	Region: {"description":"Important for inducing cell death"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQZ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UIU2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	86
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	41
Details	Domain: {"description":"CHCH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	43
Details	Domain: {"description":"CHCH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CR61","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---