5XTB
Cryo-EM structure of human respiratory complex I matrix arm
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 431 | 47323.9 | 1 | UniProt (P49821) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Homo sapiens (Human) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20314.0 | 1 | UniProt (O00217) Pfam (PF12838) | Homo sapiens (Human) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17887.9 | 1 | UniProt (O75251) Pfam (PF01058) | Homo sapiens (Human) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 4 | D (E) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 113 | 13758.1 | 1 | UniProt (P56556) Pfam (PF13233) | Homo sapiens (Human) | Complex I-B14,CI-B14,LYR motif-containing protein 6,NADH-ubiquinone oxidoreductase B14 subunit |
| 5 | E (F) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 83 | 9535.9 | 1 | UniProt (O43678) Pfam (PF05047) | Homo sapiens (Human) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 6 | F (G) | Acyl carrier protein, mitochondrial | polymer | 85 | 9845.2 | 1 | UniProt (O14561) Pfam (PF00550) | Homo sapiens (Human) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 7 | G (H) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 112 | 13119.2 | 1 | UniProt (Q16718) Pfam (PF04716) | Homo sapiens (Human) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 8 | H (I) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 110 | 12282.1 | 1 | UniProt (O95182) Pfam (PF07347) | Homo sapiens (Human) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 9 | I (J) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 337 | 38387.6 | 1 | UniProt (Q16795) Pfam (PF01370) | Homo sapiens (Human) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 10 | J (K) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 33 | 3900.3 | 1 | UniProt (P56181) Pfam (PF15880) | Homo sapiens (Human) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit,Renal carcinoma antigen NY-REN-4 |
| 11 | K (L) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 118 | 13721.6 | 1 | UniProt (O43181) Pfam (PF04800) | Homo sapiens (Human) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 12 | L (M) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 687 | 75471.5 | 1 | UniProt (P28331) Pfam (PF13510) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) | Homo sapiens (Human) | Complex I-75kD,CI-75kD |
| 13 | M (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 143 | 16880.1 | 1 | UniProt (Q9UI09) Pfam (PF05071) | Homo sapiens (Human) | 13 kDa differentiation-associated protein,Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 14 | N (O) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 212 | 23430.9 | 1 | UniProt (P19404) Pfam (PF01257) | Homo sapiens (Human) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 15 | O (P) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 208 | 24432.7 | 1 | UniProt (O75489) Pfam (PF00329) | Homo sapiens (Human) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 16 | P (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 385 | 43987.6 | 1 | UniProt (O75306) Pfam (PF00346) | Homo sapiens (Human) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 17 | Q (T) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 95 | 10578.8 | 1 | UniProt (O75380) Pfam (PF10276) | Homo sapiens (Human) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 18 | R (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 22 | 2561.0 | 1 | UniProt (Q9P0J0) | Homo sapiens (Human) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 19 | AA, S, U, V, W... (M, A, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 20 | T (A) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 21 | X (E) | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate | non-polymer | 540.7 | 1 | Chemie (8Q1) | |||
| 22 | Y (J) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 23 | BA, CA (M, O) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 397418.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 4203.9 | |
| All* | Total formula weight | 401622.3 |
