5XTB
Cryo-EM structure of human respiratory complex I matrix arm
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| A | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042775 | biological_process | mitochondrial ATP synthesis coupled electron transport |
| A | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| A | 0045271 | cellular_component | respiratory chain complex I |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| C | 0048038 | molecular_function | quinone binding |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| E | 0045271 | cellular_component | respiratory chain complex I |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0005515 | molecular_function | protein binding |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| H | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| H | 0009060 | biological_process | aerobic respiration |
| H | 0016020 | cellular_component | membrane |
| H | 0022904 | biological_process | respiratory electron transport chain |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| H | 0045271 | cellular_component | respiratory chain complex I |
| H | 1902600 | biological_process | proton transmembrane transport |
| I | 0005515 | molecular_function | protein binding |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005743 | cellular_component | mitochondrial inner membrane |
| I | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| I | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| I | 0009060 | biological_process | aerobic respiration |
| I | 0016020 | cellular_component | membrane |
| I | 0042773 | biological_process | ATP synthesis coupled electron transport |
| I | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| I | 0045271 | cellular_component | respiratory chain complex I |
| I | 1902600 | biological_process | proton transmembrane transport |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0045271 | cellular_component | respiratory chain complex I |
| L | 0022900 | biological_process | electron transport chain |
| M | 0005515 | molecular_function | protein binding |
| M | 0005739 | cellular_component | mitochondrion |
| M | 0005743 | cellular_component | mitochondrial inner membrane |
| M | 0005758 | cellular_component | mitochondrial intermembrane space |
| M | 0005759 | cellular_component | mitochondrial matrix |
| M | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| M | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| M | 0009055 | molecular_function | electron transfer activity |
| M | 0009060 | biological_process | aerobic respiration |
| M | 0016020 | cellular_component | membrane |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| M | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| M | 0042773 | biological_process | ATP synthesis coupled electron transport |
| M | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| M | 0045271 | cellular_component | respiratory chain complex I |
| M | 0045333 | biological_process | cellular respiration |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0051536 | molecular_function | iron-sulfur cluster binding |
| M | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| M | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| M | 1902600 | biological_process | proton transmembrane transport |
| N | 0005515 | molecular_function | protein binding |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0005743 | cellular_component | mitochondrial inner membrane |
| N | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| N | 0009060 | biological_process | aerobic respiration |
| N | 0016020 | cellular_component | membrane |
| N | 0042775 | biological_process | mitochondrial ATP synthesis coupled electron transport |
| N | 0042776 | biological_process | proton motive force-driven mitochondrial ATP synthesis |
| N | 0045271 | cellular_component | respiratory chain complex I |
| N | 1902600 | biological_process | proton transmembrane transport |
| O | 0016491 | molecular_function | oxidoreductase activity |
| P | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| P | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| Q | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| Q | 0048038 | molecular_function | quinone binding |
| Q | 0051287 | molecular_function | NAD binding |
| T | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 A 501 |
| Chain | Residue |
| A | ILE205 |
| A | CYS425 |
| A | PRO223 |
| A | SER378 |
| A | CYS379 |
| A | GLN381 |
| A | CYS382 |
| A | CYS385 |
| A | THR423 |
| A | ILE424 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue FMN A 502 |
| Chain | Residue |
| A | GLY87 |
| A | ARG88 |
| A | GLY89 |
| A | ASN116 |
| A | GLU119 |
| A | GLY207 |
| A | GLU208 |
| A | GLU209 |
| A | ALA243 |
| A | ASN244 |
| A | ALA426 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 B 301 |
| Chain | Residue |
| B | CYS111 |
| B | ALA113 |
| B | CYS114 |
| B | LYS115 |
| B | CYS117 |
| B | CYS160 |
| B | ALA164 |
| B | ILE165 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue SF4 B 302 |
| Chain | Residue |
| B | HIS99 |
| B | CYS121 |
| B | PRO122 |
| B | CYS150 |
| B | ILE151 |
| B | TYR152 |
| B | CYS153 |
| B | GLY154 |
| B | PHE155 |
| B | CYS156 |
| B | GLU167 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 C 301 |
| Chain | Residue |
| C | ALA87 |
| C | CYS88 |
| C | CYS89 |
| C | GLY151 |
| C | SER152 |
| C | CYS153 |
| C | CYS183 |
| C | PRO184 |
| Q | HIS223 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue 8Q1 E 201 |
| Chain | Residue |
| E | MET25 |
| E | TRP39 |
| E | MET66 |
| E | PHE67 |
| E | ASN70 |
| E | VAL79 |
| E | LEU82 |
| E | VAL83 |
| G | SER112 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue NDP J 401 |
| Chain | Residue |
| J | GLY60 |
| J | THR62 |
| J | GLY63 |
| J | PHE64 |
| J | LEU65 |
| J | ALA110 |
| J | LEU129 |
| J | ILE130 |
| J | GLY131 |
| J | ARG132 |
| J | PHE145 |
| J | SER168 |
| J | HIS169 |
| J | TYR180 |
| J | LYS184 |
| J | PRO203 |
| J | ILE206 |
| J | ARG212 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 M 801 |
| Chain | Residue |
| M | HIS124 |
| M | ASP127 |
| M | CYS128 |
| M | CYS131 |
| M | GLY134 |
| M | CYS137 |
| M | GLN140 |
| M | VAL228 |
| M | GLY229 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 M 802 |
| Chain | Residue |
| M | CYS176 |
| M | ILE177 |
| M | CYS179 |
| M | CYS182 |
| M | CYS226 |
| M | PRO227 |
| M | VAL228 |
| M | ALA230 |
| M | LEU231 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue FES M 803 |
| Chain | Residue |
| M | CYS75 |
| M | MET77 |
| M | CYS78 |
| M | CYS92 |
| M | ARG62 |
| M | CYS64 |
| M | TYR65 |
| M | ALA72 |
| M | ASN74 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue FES O 301 |
| Chain | Residue |
| O | CYS135 |
| O | THR137 |
| O | PRO139 |
| O | CYS140 |
| O | CYS176 |
| O | LEU177 |
| O | GLY178 |
| O | ALA179 |
| O | CYS180 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM |
| Chain | Residue | Details |
| G | ASP107-MET122 |
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI |
| Chain | Residue | Details |
| G | ASP132-ILE144 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP |
| Chain | Residue | Details |
| B | CYS111-PRO122 | |
| B | CYS150-PRO161 |
| site_id | PS00535 |
| Number of Residues | 12 |
| Details | COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK |
| Chain | Residue | Details |
| Q | LEU116-LYS127 |
| site_id | PS00542 |
| Number of Residues | 22 |
| Details | COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL |
| Chain | Residue | Details |
| P | GLU167-LEU188 |
| site_id | PS00641 |
| Number of Residues | 18 |
| Details | COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC |
| Chain | Residue | Details |
| M | PRO61-CYS78 |
| site_id | PS00642 |
| Number of Residues | 13 |
| Details | COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ |
| Chain | Residue | Details |
| M | CYS128-GLN140 |
| site_id | PS00643 |
| Number of Residues | 11 |
| Details | COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF |
| Chain | Residue | Details |
| M | ARG175-PHE185 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES |
| Chain | Residue | Details |
| A | GLY200-SER215 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG |
| Chain | Residue | Details |
| A | GLU377-GLY388 |
| site_id | PS01099 |
| Number of Residues | 19 |
| Details | COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP |
| Chain | Residue | Details |
| O | ASP166-PRO184 |
| site_id | PS01150 |
| Number of Residues | 17 |
| Details | COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP |
| Chain | Residue | Details |
| C | GLY169-PRO185 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P52503 |
| Chain | Residue | Details |
| T | LYS98 | |
| Q | CYS332 | |
| Q | CYS347 | |
| M | CYS92 | |
| M | CYS176 | |
| M | CYS179 | |
| M | CYS182 | |
| M | CYS226 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine => ECO:0000269|PubMed:24089531, ECO:0000269|PubMed:24838397 |
| Chain | Residue | Details |
| Q | ARG118 | |
| O | CYS180 | |
| M | CYS131 | |
| M | CYS137 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D6J6 |
| Chain | Residue | Details |
| O | LYS61 | |
| M | LYS467 | |
| M | LYS499 | |
| M | LYS709 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:22823520 |
| Chain | Residue | Details |
| O | TYR193 | |
| A | LYS375 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q91YT0 |
| Chain | Residue | Details |
| A | ARG257 |
